2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Elastase CFTR
  4. Neltenexine

Neltenexine 是一种黏液溶解剂，也是弹性蛋白酶 (Elastase) 抑制剂。Neltenexine 通过抑制 Na/K/2Cl++− 和 Na+/HCO3− 共转运蛋白对 Cl− 和 HCO3− 的摄取来减少支气管上皮细胞的阴离子分泌，且不阻断 CFTR 通道；此外，它还能通过刺激 Cl−/HCO3− 交换器来减少阴离子分泌。Neltenexine 能显著预防弹性蛋白酶诱导的大鼠模型中的肺气肿，并减少肺泡变形。Neltenexine 可用于慢性阻塞性肺疾病 (COPD) 等肺部疾病的研究。

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Neltenexine

Neltenexine Chemical Structure

CAS No. : 99453-84-6

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Neltenexine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research[1][2].

分子量

488.24

Formula

C18H20Br2N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neltenexine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neltenexine99453-84-6ElastaseCFTRCystic fibrosis transmembrane conductance regulatorCOPDAnion secretionInhibitorinhibitorinhibit

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