2. Neuronal Signaling GPCR/G Protein Metabolic Enzyme/Protease Apoptosis
  3. Cholinesterase (ChE) Cannabinoid Receptor Aldehyde Dehydrogenase (ALDH) Caspase Apoptosis
  4. Neuroprotective agent 15

Neuroprotective agent 15 (Compound 3e) 是一种神经保护剂。Neuroprotective agent 15 是一种选择性的丁酰胆碱酯酶 (BChE) 抑制剂，其对 BChE 和 AChE 的 IC50 为 2.6 和 114.3 μM。Neuroprotective agent 15 具有大麻素 CB2 受体 (CB2 receptor) 激动活性。Neuroprotective agent 15 可降低细胞死亡，LDH 释放和 Caspase-3/7 活性，抑制细胞凋亡 (apoptosis)。Neuroprotective agent 15 可减少超氧化物自由基形成，维持细胞形态，进而降低氧化应激水平。Neuroprotective agent 15 可用于研究神经退行性疾病，如阿尔茨海默症、帕金森病等。

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Neuroprotective agent 15

Neuroprotective agent 15 Chemical Structure

CAS No. : 2476614-40-9

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Neuroprotective agent 15 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

查看 Cannabinoid Receptor 亚型特异性产品:

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CB1 CB2

查看 Aldehyde Dehydrogenase (ALDH) 亚型特异性产品:

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ALDH1 ALDH2 ALDH3

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

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  • 参考文献

生物活性

Neuroprotective agent 15 (Compound 3e) is a neuroprotective agent. Neuroprotective agent 15 is a selective butyrylcholinesterase (BChE) inhibitor, with IC50 values of 2.6 and 114.3 μM for BChE and AChE respectively. Neuroprotective agent 15 has cannabinoid CB2 receptor (CB2 receptor) agonistic activity. Neuroprotective agent 15 can reduce cell death, LDH release and Caspase-3/7 activity, and inhibit apoptosis. Neuroprotective agent 15 can reduce the formation of superoxide free radicals, maintain cell morphology, and significantly lower oxidative stress levels. Neuroprotective agent 15 can be used in the research of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease[1].

IC50 & Target[1]

CB2

 

BChE

2.6 μM (IC50)

AChE

114.3 μM (IC50)

Caspase 3

 

Caspase-7

 

分子量

364.44

Formula

C20H24N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuroprotective agent 15 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroprotective agent 152476614-40-9Neuroprotective agent15Neuroprotective agent-15Cholinesterase (ChE)Cannabinoid ReceptorAldehyde Dehydrogenase (ALDH)CaspaseApoptosisNeuroprotectionPurinesSH-SY5Y cells3-Nitropropionic acidGlutamatemCholinesterasesCannabinoid receptorsInhibitorinhibitorinhibit

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