Neutrophil elastase-IN-7

目录号: HY-160824 一键复制产品信息: Data Sheet 产品使用指南
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Neutrophil elastase-IN-7 (Compound 12) 是一种有效的中性粒细胞弹性蛋白酶 (HNE) 抑制剂，其 IC₅₀ 值为 0.54 μM。Neutrophil elastase-IN-7 对多种凝血蛋白也表现出显著的抑制活性，对凝血酶 (thrombin)、FXa、FXIa 和 FXIIIa 的 IC₅₀ 值分别为 8.2、12.7、1.2 和 5.7 μM。Neutrophil elastase-IN-7 可用于研究炎症、先天免疫反应和组织重塑。

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CAS No. : 6968-33-8

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Neutrophil elastase-IN-7 的其他形式现货产品:

Evans Blue

Customer Review

Other Forms of Neutrophil elastase-IN-7:

Evans Blue In-stock

MCE 顾客使用本产品发表的 28 篇科研文献

In Vivo Efficacy Study

: Neutrophil elastase-IN-7 purchased from MCE. Usage Cited in: Theranostics. 2023 Jun 26;13(11):3761-3780. [Abstract]; Sufu-cKO and WT mice were intraperitoneally injected with PBS or LPS (5 mg/kg) for 23 h, then injected with Evans blue dye (30 mg/kg body weight; i.v.; single dose) for an additional 40 min before mice were killed and lung tissues harvested. Means ± SEM (n = 5).

: Neutrophil elastase-IN-7 purchased from MCE. Usage Cited in: Adv Healthc Mater. 2024 Jan;13(3):e2302320. [Abstract]; The effects of different groups (control, CLP, Ca-MOF, Zolif, CMZ, RCMZ, and γ3-RCMZ) on CLP-induced vascular permeability were examined by measuring Evans blue dye in peritoneal washings. Evans blue (10 mg/kg; i.v.; single dose) injection revealed that γ3-RCMZ effectively reduced endothelial leakage levels to one-sixth of those observed in the CLP group, indicating its predominant antiendothelial leakage effect in sepsis.

: Neutrophil elastase-IN-7 purchased from MCE. Usage Cited in: Int J Biol Macromol. 2025 Oct 4;330(Pt 3):148106. [Abstract]; Representative images of injured spinal cord in the control, ZFgf11a, and MFGF11b groups after Evans Blue (EB, 2 mL/kg, i.v.; single dose) dye injection at 4 dpi.

: Neutrophil elastase-IN-7 purchased from MCE. Usage Cited in: Int J Biol Macromol. 2025 Oct 4;330(Pt 3):148106. [Abstract]; Representative immunofluorescence images of Evans Blue (EB, 2 mL/kg, i.v.; single dose) extravasation at the lesion epicenter in the transverse sections of the spinal cord in the control, ZFgf11a, and MFGF11b groups at 4 dpi.

: Neutrophil elastase-IN-7 purchased from MCE. Usage Cited in: Cancer Immunol Immunother. 2025 Jul 12;74(8):268. [Abstract]; Representative images of Evans blue (4 ml/kg; i.v.; single dose) leakage and the difference between TGF-β3 and PBS groups (n = 5).