2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel Potassium Channel Sodium Channel
  4. NIP 142

NIP-142 是一种苯并吡喃衍生物，具有多重离子通道阻断作用。NIP-142 通过选择性阻断心房肌中富集的钾离子通道，延长心房有效不应期 (ERP) 和动作电位时程 (APD)，而对心室复极化影响极小。NIP-142 还抑制 L 型/T 型钙通道和钠通道，进一步贡献其抗心律失常效果。NIP-142 在多种房颤模型中表现出显著疗效。NIP-142 可用于研究心律失常。

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NIP 142

NIP 142 Chemical Structure

CAS No. : 203002-58-8

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NIP 142 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NIP-142 is a benzopyran derivative with multiple ion channel-blocking effects. NIP-142 selectively blocks the potassium ion channels enriched in atrial muscle, prolonging the effective refractory period (ERP) and action potential duration (APD) of the atrium, while having minimal effect on ventricular repolarization. NIP-142 also inhibits L-type/T-type calcium channels and sodium channels, further contributing to its anti-arrhythmic effect. NIP-142 shows significant efficacy in various atrial fibrillation models. NIP-142 can be used for research on arrhythmias[1].

IC50 & Target[1]

L-type calcium channel

 

T-type calcium channel

 

分子量

441.48

Formula

C23H27N3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NIP 142 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NIP 142203002-58-8NIP142NIP-142Calcium ChannelPotassium ChannelSodium ChannelCa2+ channelsCa channelsKcsANa channelsNa+ channelsAtrial fibrillationAntiarrhythmicsIon channelsInhibitorinhibitorinhibit

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