2. Others Metabolic Enzyme/Protease
  3. Fluorescent Dye Endogenous Metabolite
  4. NIR‐fluorescent ceramide

NIR‐fluorescent ceramide 是一种基于 C 桥连硝基苯并二唑 SCOTfluor 核心的中性近红外 (NIF) 荧光探针，能可视化鞘脂转运等脂质代谢过程。NIR‐fluorescent ceramide 在脂质体环境中其发射信号会显著增强。NIR‐fluorescent ceramide 能够作为细胞内转运示踪剂，在短时间内定位于内质网和高尔基体周围区域，随后在较长时间内转移至循环溶酶体，从而实现对活细胞中鞘脂转运和生物脂质功能的实时可视化。NIR‐fluorescent ceramide 还能在人类癌细胞系中产生代谢摄取特征并提供多重代谢读数。

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NIR‐fluorescent ceramide

NIR‐fluorescent ceramide Chemical Structure

CAS No. : 2351937-34-1

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NIR‐fluorescent ceramide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NIR-fluorescent ceramide is a neutral near-infrared fluorescent (NIF) probe based on the C-bridged nitrobenzoxadiazole SCOTfluor core, which enables visualization of lipid metabolic processes such as sphingolipid trafficking. The emission signal of NIR-fluorescent ceramide is significantly enhanced in liposomal environments. As an intracellular trafficking tracer, NIR-fluorescent ceramide localizes to regions surrounding the endoplasmic reticulum and Golgi apparatus within a short period, then translocates to circulating lysosomes over a longer period, thereby enabling real-time visualization of sphingolipid trafficking and biological lipid functions in living cells. NIR-fluorescent ceramide also generates metabolic uptake profiles and provides multiple metabolic readouts in human cancer cell lines[1][2].

体外研究
(In Vitro)

NIR‐fluorescent ceramide 在磷脂酰胆碱/胆固醇比例为 7:1 的脂质体中荧光发射强度提升约 15 倍，表现出荧光响应特性[1]。
NIR‐fluorescent ceramide (50 nM; 15 min, 3 h) 在处理 A549 细胞后的 15 min 时主要定位于 A549 细胞的内质网，至处理后 3 h 时则转运至循环溶酶体[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NIR‐fluorescent ceramide 相关抗体:

Immunofluorescence[1]

Cell Line: human A549 lung cancer cells
Concentration: 50 nM
Incubation Time: 15 min (imaging); 3 h (imaging)
Result: Showed high co-localization with ER Tracker Green (co-localization coefficient R = 0.91) and low co-localization with LysoTracker Blue (R = 0.26) at 15 min post-treatment.
Showed increased co-localization with LysoTracker Blue (R = 0.75) and reduced co-localization with ER Tracker Green (R = 0.49) at 3 h post-treatment.
分子量

601.82

Formula

C33H55N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NIR‐fluorescent ceramide 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NIR‐fluorescent ceramide2351937-34-1Fluorescent DyeEndogenous MetaboliteMRC5 cellsendoplasmic reticulumhuman cancer cell linesliposomal environmentsbiolipid functionLN18 cellssphingolipid traffickingrecycling lysosomesA549 cellsGolgi apparatusInhibitorinhibitorinhibit

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