2. Anti-infection
  3. RSV
  4. Nirsevimab

Nirsevimab  (Synonyms: 尼塞韦单抗; MEDI8897)

目录号: HY-P99756 纯度: 98.00%
COA 技术支持

Nirsevimab (MEDI8897) 是一种重组人呼吸道合胞病毒 (RSV) 单克隆抗体。Nirsevimab 对 RSV A 和 RSV B 病毒具有中和活性，IC50 值分别为 5.42 ng/mL 和 9.71 ng/mL。Nirsevimab 可以用于呼吸道感染的研究。

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CAS No. : 1989556-22-0

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规格 价格 是否有货 数量
1 mg ￥4000
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Nirsevimab 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections[1][2].
同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

RSV-F
体外研究
(In Vitro)

Nirsevimab 可以直接中和 RSV 病毒并具有片段可结晶 (Fc) 介导的效应器功能，从而预防呼吸道感染[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nirsevimab 相关抗体:
体内研究
(In Vivo)

Nirsevimab (10-10000 μg/kg; 肌肉注射) 在 RSV 病毒感染前预先给药可以抑制小鼠呼吸道粘膜的抗体反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3-week-old female BALB/c mice[2].
Dosage: 10 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Intramuscular injection (i.m.); administer medication 24 hours prior to RSV virus exposure
Result: Inhibited the secretion of sIgA, mucosal IgA, and mucosal IgG in the offspring subsequent to the initial RSV infection.
Clinical Trial
Accession

A0A0X8XRK2
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

146.31 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

尼塞韦单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Fusion glycoprotein F0/F Protein, HRSV (sf9, His, HY-P75182) can bind Nirsevimab. The EC50 for this effect is 44 ng/mL.
纯度 & 产品资料
参考文献

Nirsevimab 相关分类

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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nirsevimab1989556-22-0MEDI8897尼塞韦单抗MEDI 8897MEDI-8897RSVRespiratory syncytial virusantibodyrespiratory tract infectionInhibitorinhibitorinhibit

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