1. Immunology/Inflammation Apoptosis
  2. Interleukin Related TNF Receptor COX NO Synthase
  3. Nitroparacetamol

Nitroparacetamol  (Synonyms: NCX-701)

目录号: HY-119348
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Nitroparacetamol (NCX-701) 是一种一氧化氮 (NO) 供体-非甾体抗炎剂 (NO-NSAID)。Nitroparacetamol 由 Acetaminophen (HY-66005) 和 Nitrooxybutyroyl 通过酯键连接而成,旨在结合 Acetaminophen 的镇痛优势与一氧化氮的器官保护作用,同时拓展其抗炎活性。Nitroparacetamol 的镇痛谱更广,且对疼痛性病理性疼痛有效,且显著降低肝毒性。Nitroparacetamol 可降低 IL-1βTNF-αCOX-2 iNOS 表达。

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Nitroparacetamol

Nitroparacetamol Chemical Structure

CAS No. : 326850-30-0

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  • 生物活性

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生物活性

Nitroparacetamol (NCX-701) is a nitric oxide (NO) donor-non-steroidal anti-inflammatory agent (NO-NSAID). Nitroparacetamol is formed by the ester linkage of Acetaminophen (HY-66005) and Nitrooxybutyroyl, aiming to combine the analgesic advantage of Acetaminophen with the organ-protective effect of nitric oxide, while expanding its anti-inflammatory activity. The analgesic spectrum of Nitroparacetamol is broader, and it is effective for painful pathological pain, and significantly reduces hepatotoxicity. Nitroparacetamol can reduce the expressions of IL-1β, TNF-α, COX-2, and iNOS.

分子量

282.25

Formula

C12H14N2O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Nitroparacetamol
目录号:
HY-119348
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