2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. NMDA-IN-1 dihydrochloride

NMDA-IN-1 dihydrochloride 是一种选择性的 NMDA NR2B 抑制剂，其 Ki 值为 0.85 nM。NMDA-IN-1 dihydrochloride 能够抑制表达 hNR1a/NR2B 的 Ltk 细胞中由谷氨酸/甘氨酸刺激产生的钙离子通量，其 IC50 为 9.7 nM。NMDA-IN-1 dihydrochloride 对 NR2A、NR2C、NR2D、hERG 通道和 α1 肾上腺素能受体均无作用。NMDA-IN-1 dihydrochloride 在大鼠的机械性痛觉过敏测试中表现出优异的活性。NMDA-IN-1 dihydrochloride 可用于中风、帕金森疾病和神经性疼痛的研究。

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NMDA-IN-1 dihydrochloride

NMDA-IN-1 dihydrochloride Chemical Structure

CAS No. : 1784252-90-9

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规格 价格 是否有货 数量
1 mg ￥798
3 - 4 周
5 mg ￥2393
3 - 4 周
10 mg ￥3828
3 - 4 周
25 mg 询价 3 - 4 周
50 mg   询价  
100 mg   询价  

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Other Forms of NMDA-IN-1 dihydrochloride:

NMDA-IN-1 dihydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NMDA-IN-1 dihydrochloride is a selective NMDA NR2B antagonist with a Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM. NMDA-IN-1 dihydrochloride inhibits Glu/Gly stimulated Ca2+ flux in Ltk- cells expressing the hNR1a/NR2B with a IC50 of 9.7 nM. NMDA-IN-1 dihydrochloride has no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. NMDA-IN-1 dihydrochloride shows excellent activity in the mechanical hyperalgesia assay in rats. NMDA-IN-1 dihydrochloride can be used for the studies of stroke, parkinson, and neuropathic pain[1].

体内研究
(In Vivo)

NMDA-IN-1 dihydrochloride (Compound 37a) (1, 3 and 10 mg/kg, i.v., 单次给药) 在角叉菜胶诱导的大鼠机械性痛觉模型中展现了较好的活性，其 ED50 值 <3 mg/kg[1]。
NMDA-IN-1 (30 mg/kg, 大鼠和 3 mg/kg, 犬, p.o., 单次给药) 在大鼠体内其口服生物利用度较差，但在犬体内却表现出良好的药代动力学特征[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

412.33

Formula

C20H24Cl2FN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NMDA-IN-1 dihydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NMDA-IN-11784252-90-9iGluRIonotropic glutamate receptorsCentral nervous systemDogsCarrageenan-induced mechanical hyperalgesia assayInhibitorinhibitorinhibit

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