2. Anti-infection
  3. Reverse Transcriptase HIV
  4. NNRT-IN-15

NNRT-IN-15 (Compound 16a) 是一种强效的非核苷类逆转录酶 (NNRT) 抑制剂。NNRT-IN-15 对野生型 HIV-1 的 EC50 为 3 nM，并能抑制七种突变株 (L100I、K103N、Y181C 等) (EC50 = 8.2-43.4 nM)。NNRT-IN-15 对 MT-4 细胞的细胞毒性较低 (CC50 = 196.46 μM)。NNRT-IN-15 还能抑制野生型 HIV-1 RT 和 hERG 通道，IC50 值分别为 0.7599 μM 和 27.455 μM。 NNRT-IN-15 可用于 HIV-1 感染的研究。

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NNRT-IN-15

NNRT-IN-15 Chemical Structure

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NNRT-IN-15 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

查看所有亚型
HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NNRT-IN-15 (Compound 16a) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-15 shows an EC50 of 3 nM for WT HIV-1 and inhibits seven mutant strains (L100I, K103N, Y181C, etc.) (EC50 = 8.2-43.4 nM). NNRT-IN-15 has low cytotoxicity against MT-4 cells (CC50 = 196.46 μM). NNRT-IN-15 also inhibit WTHIV-1RT and hERG with IC50 values of 0.7599 μM and 27.455 μM. NNRT-IN-15 can be used for research of HIV-1 infection[1].

IC50 & Target[1]

HIV-1

 

药代动力学
(Parmacokinetics)
Species Dose Route Indicator value
Rat[1] 1 mg/kg i.v. T1/2 4.24 h
Rat[1] 10 mg/kg p.o. T1/2 2.45 h
Rat[1] 1 mg/kg i.v. Tmax 0.08 h
Rat[1] 10 mg/kg p.o. Tmax 1.5 h
Rat[1] 1 mg/kg i.v. Cmax 800 ng/mL
Rat[1] 10 mg/kg p.o. Cmax 29 ng/mL
Rat[1] 1 mg/kg i.v. AUC0-t 352 ng·h/mL
Rat[1] 10 mg/kg p.o. AUC0-t 79 ng·h/mL
Rat[1] 1 mg/kg i.v. AUC0-∞ 385 ng·h/mL
Rat[1] 10 mg/kg p.o. AUC0-∞ 86 ng·h/mL
Rat[1] 1 mg/kg i.v. MRT0-t 1.03 h
Rat[1] 10 mg/kg p.o. MRT0-t 2.41 h
Rat[1] 1 mg/kg i.v. MRT0-∞ 2.23 h
Rat[1] 10 mg/kg p.o. MRT0-∞ 3.18 h
Rat[1] 1 mg/kg i.v. Vz 16.46 L/kg
Rat[1] 10 mg/kg p.o. F 2.06 %
Rat[1] 1 mg/kg i.v. CL 3815 mL/min/kg
分子量

636.77

Formula

C34H36N8O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NNRT-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NNRT-IN-15Reverse TranscriptaseHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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产品名称：
NNRT-IN-15
目录号：
HY-181034
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