2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. NOTA-TATE

NOTA-TATE 是生长抑素受体 2 (SSTR2) 结合剂。NOTA-TATE 可与 SSTR2 结合，从而实现对 SSTR2 阳性肿瘤细胞的靶向定位，用于 PET 成像。NOTA-TATE 可用于神经内分泌肿瘤的研究。

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Custom Peptide Synthesis

NOTA-TATE

NOTA-TATE Chemical Structure

CAS No. : 709043-21-0

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NOTA-TATE 相关抗体

Top Publications Citing Use of Products

查看 Somatostatin Receptor 亚型特异性产品:

查看所有亚型
SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours[1].

体内研究
(In Vivo)

68Ga-NOTA-TATE (0.1 mCi/2.96 MBq；静脉注射；单次给药) 在注射后 1 小时内，于荷 AR42J 瘤裸鼠体内表现出与68Ga-DOTA-TATE 相当的肿瘤摄取量，且在 micro-PET/CT 上可清晰显影肿瘤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (15-20 g; 2 females and 2 males per group for 15 min, 30 min, 1 h, 2 h time points; 3 females and 3 males for imaging; AR42J pancreatic tumour xenografts)[1]
Dosage: 0.1 mCi (8.8 GBq/mg) (biodistribution); 2.96 MBq (0.08 mCi) (imaging)
Administration: i.v.; single dose
Result: Reached tumour uptake of 3.24 ± 1.03 %ID/g at 15 min, 3.97 ± 2.24 %ID/g at 30 min, 3.16 ± 1.92 %ID/g at 1 h, and 1.33 ± 0.96 %ID/g at 2 h post-injection; Showed clear tumour visualization on micro-PET/CT images at 30 min and 2 h post-injection; Displayed intense radioactivity in gallbladder on imaging.
分子量

1334.52

Formula

C61H83N13O17S2
CAS 号
Sequence

{dPhe-NOTA}-Cys-Tyr-dTrp-Lys-Thr-Cys-Thr (disulfide bridge:Cys2-Cys7)
Sequence Shortening

{dPhe-NOTA}-CY-dTrp-KTCT (disulfide bridge:Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NOTA-TATE 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOTA-TATE709043-21-0Somatostatin ReceptorSSTRsSSTRhuman serumSSTR2-positive tumour cellsSSTR2human plasmaKunming micePET imaging agentsomatostatin receptor 2AR42J tumour-bearing nude miceneuroendocrine tumoursInhibitorinhibitorinhibit

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产品名称：
NOTA-TATE
目录号：
HY-P11655
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