2. Neuronal Signaling Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. α-synuclein Caspase Reactive Oxygen Species (ROS)
  4. NPT100-18A

NPT100-18A 是一种 α-突触核蛋白寡聚化抑制剂。NPT100-18A 可将裂解的 caspase-3 恢复至正常水平。NPT100-18A 以区室特异性的方式减弱线粒体氧化应激探针的水平，并且在高浓度下可增加 ATP 信号。NPT100-18A 可用于帕金森病 (PD) 的研究。

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NPT100-18A

NPT100-18A Chemical Structure

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NPT100-18A 相关抗体

Top Publications Citing Use of Products

查看 α-synuclein 亚型特异性产品:

查看所有亚型
α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NPT100-18A is an αSyn oligomerization inhibitor. NPT10018A rescues cleaved caspase-3 levels to control levels. NPT10018A attenuates mitochondrial oxidative stress probe levels in a compartment-specific manner and, at higher concentrations, increases ATP signals. NPT100-18A can be used for the study of Parkinson’s disease (PD)[1][2].

IC50 & Target

Caspase 3

 

体外研究
(In Vitro)

NPT100-18A (10 nM) 可降低 iPSC 来源的 mDAN 中 Triton-X100 不溶性 α-突触核蛋白聚集体的数量[1]。
NPT100-18A (10 nM) 可特异性降低 iPSC 来源的 mDAN 中的线粒体 ROS 水平，而不影响细胞内总 ROS 水平[1]。
NPT100-18A (1 µM) 可显著增强 iPSC 来源的 mDAN 中的 ATP 信号传导[1]。
NPT100-18A (10 nM，21 天) 可显著降低 iPSC 来源的 mDAN 中 cCasp3⁺ 神经元的比例，并抑制 α-突触核蛋白相关的早期神经元凋亡通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NPT100-18A 相关抗体:
体内研究
(In Vivo)

NPT100-18A (1-20 mg/kg，腹腔注射，每日一次，持续 90 天) 显著改善了 mThy1-wt-α-syn 转基因小鼠的运动功能障碍，并减少了 α-syn 寡聚体和相关的神经退行性病理[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mThy1-wt-α-syn transgenic mice[2].
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: I.p., once daily for 90 days
Result: 10 and 20 mg/kg significantly reduced foot slips.
10 mg/kg significantly improved the error rate in the Challenger beam test.
Accumulation of α-synuclein in neurons and neurites was reduced.
SDS-resistant α-synuclein oligomers were reduced.
α-synuclein changed from a membrane component to a cytoplasmic component.
Animal Model: mThy1-E57K-α-syn transgenic mice[2].
Dosage: 20 mg/kg
Administration: I.p., once daily for 90 days
Result: Significantly reduced α-syn dimer/trimer/polymers.
Oligomer accumulation decreased markedly.
分子量

493.64

Formula

C28H39N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NPT100-18A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPT100-18Aα-synucleinCaspaseReactive Oxygen Species (ROS)α-SynParkinson’s diseaseAlpha-synucleinAggregationOxidative stressROSiPSCDopaminergic neuronsMitochondriaInhibitorinhibitorinhibit

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