2. NF-κB Apoptosis
  3. Keap1-Nrf2 Apoptosis Caspase
  4. Nrf2 activator-21

Nrf2 activator-21 是一种具有双重抗氧化和神经保护特性的 Nrf2 激活剂。Nrf2 activator-21 与 Keap1 Kelch 结构域结合，破坏 Keap1-Nrf2 相互作用，并激活抗氧化防御机制。Nrf2 activator-21 减少海马神经元的凋亡 (apoptosis) 并降低 caspase-3 活性。Nrf2 activator-21 通过激活 Nrf2 途径靶向脑缺血/再灌注损伤 (CIRI)。Nrf2 activator-21 改善神经功能，缓解大鼠双血管闭塞 (2VO) 诱导的 CIRI 的焦虑样行为，并增强记忆。Nrf2 activator-21 可用于脑缺血/再灌注损伤研究。

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Nrf2 activator-21

Nrf2 activator-21 Chemical Structure

CAS No. : 1912404-14-8

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  • 生物活性

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生物活性

Nrf2 activator-21 is a Nrf2 activator with dual antioxidant and neuroprotective properties. Nrf2 activator-21 binds to Keap1 Kelch domain and disrupts Keap1-Nrf2 interactions and activate antioxidant defense mechanisms. Nrf2 activator-21 reduces apoptosis and decreases caspase-3 activity in the hippocampal neurons. Nrf2 activator-21 targets cerebral ischemia/reperfusion injury (CIRI) via Nrf2 pathway activation. Nrf2 activator-21 improves neurological function, alleviates anxiety-like behavior, enhances memory in rats with 2-vessel occlusion (2VO)-induced CIRI. Nrf2 activator-21 can be used for the study of cerebral ischemia/reperfusion injury[1].

体外研究
(In Vitro)

Nrf2 activator-21 (Compound 7I) (1-15 μM，24 小时) 显著改善暴露于 H2O2 的海马神经元细胞的存活率[1]。
Nrf2 activator-21 (2.5 μM，24 小时) 减少海马神经元的凋亡并降低 caspase-3 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nrf2 activator-21 相关抗体:

Apoptosis Analysis[1]

Cell Line: hippocampal neurons
Concentration: 2.5 μM
Incubation Time: 24 h
Result: Reduced apoptosis and decreased caspase-3 activity in the hippocampal neurons.
体内研究
(In Vivo)

Nrf2 activator-21 (Compound 7I) (15 mg/kg，腹腔注射，单次给药，再灌注后 15 分钟) 显著改善雄性成年 Wistar 大鼠双血管闭塞 (2VO) 诱导的脑缺血/再灌注损伤的神经功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult Wistar rats: a midline neck incision was made to isolate bilateral common carotid arteries, which were then clamped simultaneously for 15 min to induce cerebral ischemia, followed by 15 min of reperfusion to establish the 2-vessel occlusion (2VO) cerebral ischemia/reperfusion injury model[1]
Dosage: 15 mg/kg
Administration: i.p. once 15 min post-reperfusion
Result: Achieved significant improvements in motor function, sensory response, and wire cage climbing ability, with total neurological deficit scores notably reduced in 2VO model rats.
Showed alleviation of anxiety-like behavior.
Improved memory function, with the discrimination index significantly increased in the Novel Object Recognition Test, reversing memory deficits induced by cerebral ischemia/reperfusion injury .
Preserved hippocampal CA1 neuron morphology and reduced the number of degenerated dark neurons and decreased hippocampal caspase-3 activity.
Increased hippocampal Nrf2 protein expression, restored SOD and CAT activities to near-sham levels and reduced MDA levels .
Upregulated hippocampal BDNF and TrkB receptor levels and enhanced neuroprotective signaling.
分子量

322.31

Formula

C19H14O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nrf2 activator-21 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 activator-211912404-14-8Keap1-Nrf2ApoptosisCaspaseischemia/reperfusion injuryNrf22-vessel occlusionInhibitorinhibitorinhibit

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