2. 疾病领域
  3. 神经系统疾病
  4. NS 1231

NS 1231 是一种具有神经营养样作用和神经保护效应的化合物。NS 123 1可挽救神经生长因子 (NGF) 诱导的 PC12 细胞免于因停止营养因子而导致的死亡。NS 1231 还能刺激 NGF 诱导的未分化 PC12 细胞神经突生长。NS 1231 可用于神经系统疾病的研究，如中风。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NS 1231

NS 1231 Chemical Structure

CAS No. : 309711-72-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

NS 1231 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NS 1231 is a neurotrophic-like compound with neuroprotective effect. NS 1231 can rescue nerve growth factor (NGF)-differentiated PC12 cells from death induced by withdrawal of trophic factors. NS 1231 can stimulate NGF-induced neurite outgrowth of undifferentiated PC12 cells. NS 1231 can be used for the research of neurological disease, such as stroke[1].

体外研究
(In Vitro)

NS 1231 (1-10 μM) 在 NGF 分化的 PC12 细胞去除营养因子 (血清和 NGF) 后处理 4 天，可提高细胞存活率，且保护存活细胞的神经突[1]。
NS 1231 (1-3 μM, 48 h) 与 NGF 联合处理未分化 PC12 细胞，可显著促进神经突生长[1]。
NS 1231 (1-3 μM, 5 mins) 与 NGF 联合刺激未分化 PC12 细胞，可增强 NGF 诱导的 TrkA (Shc 结合位点 Tyr490) 磷酸化和 ERK (Thr202/Tyr204) 激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NS 1231 相关抗体:
体内研究
(In Vivo)

NS 1231 (15 mg/kg，腹腔注射，MCAO 后 2 分钟) 可减少大脑中动脉闭塞 (MCAO) 小鼠的总梗死体积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with middle cerebral artery occlusion (MCAO)[1]
Dosage: 15 mg/kg
Administration: Intraperitoneally injection, 2 mins after MCAO
Result: Reduced the total infarct volume by 43% after 4 days.
分子量

326.78

Formula

C18H15ClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NS 1231 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS 1231309711-72-6NS1231NS-1231OthersNeurotrophicNeuroprotectiveNGFPC12MCAOstrokeInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
NS 1231
目录号：
HY-165616
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z