2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. nTRD22

nTRD22 是一种靶向 TDP-43 的 RNA 结合变构调节剂。nTRD22 可结合 TDP-43 N 端结构域，从而变构调控 TDP-43 的 RNA 结合结构域并降低其 RNA 结合能力。nTRD22 可降低原代运动神经元中的 TDP-43 蛋白水平。nTRD22 可缓解肌萎缩侧索硬化症模型中的运动障碍。nTRD22 可用于肌萎缩侧索硬化症的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

nTRD22

nTRD22 Chemical Structure

CAS No. : 1065567-62-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

nTRD22 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. nTRD22 binds to the N-terminal domain of TDP-43, thereby allosterically regulating the RNA-binding domain of TDP-43 and reducing its RNA-binding ability. nTRD22 decreases the TDP-43 protein level in primary motor neurons. nTRD22 alleviates motor dysfunction in amyotrophic lateral sclerosis models. nTRD22 is applicable to related research on amyotrophic lateral sclerosis[1].

体外研究
(In Vitro)

nTRD22 (0.03 μM-1 mM) 与全长 TDP-431-260 结合的表观 Kd 为 145 μM，与分离的 N 端结构域 TDP-431-102 结合的表观 Kd 为 96 μM[1]。
nTRD22 可在 alpha 实验中抑制 TDP-431-260 与 UG6 RNA 的结合，其 IC50 约为 100 μM[1]。
nTRD22 (0.1-500 μM) 可抑制 TDP-431-260 与 (UG)6 RNA 的结合，其 IC50 约为 145 μM；在 SPR 实验中对该相互作用的抑制率可达约 30%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

nTRD22 相关抗体:
体内研究
(In Vivo)

nTRD22 (50 μM; 混饲) 可显著缓解 ALS 果蝇模型中的运动障碍，且在老年果蝇中的挽救效果更显著[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GAL4-UAS bipartite expression system line (overexpressing human TDP-43 in motor neurons)[1]
Dosage: 50 μM
Administration: incorporated into fly food; continuous exposure
Result: Significantly improved motor performance, with a greater percentage of flies crossing the target climbing line over the 2-minute assay period compared to control groups.
Showed increased rescue effect in aged flies.
分子量

413.39

Formula

C19H22F3N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

nTRD22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nTRD221065567-62-5nTRD 22nTRD-22DNA/RNA SynthesisDrosophilaamyotrophic lateral sclerosisRNATDP-43 N-terminal domainRNA-binding RRM regionprimary motor neuronsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
nTRD22
目录号：
HY-181846
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z