2. Vitamin D Related/Nuclear Receptor Apoptosis MAPK/ERK Pathway
  3. Nuclear Hormone Receptor 4A/NR4A Apoptosis ASK1 JNK p38 MAPK
  4. Nur77 antagonist 2

Nur77 antagonist 2 (Compound 12b) 是一种口服有效的 Nur77 拮抗剂，其 KD 值为 0.42 μM。Nur77 antagonist 2 对肝癌细胞具有增殖活性。Nur77 antagonist 2 通过抑制其泛素-蛋白酶体的降解来稳定 Nur77，通过 ASK1-JNK/p38 途径导致 Nur77 依赖的细胞凋亡 (apoptosis)。Nur77 antagonist 2 在 HCCLM3 异种移植模型中抑制了肿瘤生长。Nur77 antagonist 2 可用于研究肝细胞癌 (HCC)。

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Nur77 antagonist 2

Nur77 antagonist 2 Chemical Structure

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Nur77 antagonist 2 相关抗体

Top Publications Citing Use of Products

查看 Nuclear Hormone Receptor 4A/NR4A 亚型特异性产品:

查看所有亚型
Nur77/NR4A1 Nurr1/NR4A2

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nur77 antagonist 2 (Compound 12b) is an orally active Nur77 antagonist with a KD value of 0.42 μM. Nur77 antagonist 2 exhibits proliferative activity on liver cancer cells. Nur77 antagonist 2 stabilizes Nur77 by inhibiting its ubiquitin-proteasomal degradation, leading to Nur77-dependent apoptosis via the ASK1-JNK/p38 pathway. Nur77 antagonist 2 inhibits tumor growth in the HCCLM3 xenograft model. Nur77 antagonist 2 can be used for the study of hepatocellular carcinoma (HCC)[1].

IC50 & Target[1]

Nur77/NR4A1

0.42 μM (Kd)

分子量

447.49

Formula

C26H21N7O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nur77 antagonist 2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nur77 antagonist 2Nuclear Hormone Receptor 4A/NR4AApoptosisASK1JNKp38 MAPKNuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptorApoptosis signal-regulating kinase 1MAP3K5MAPKKK5Mitogen-activated protein kinase kinase kinase 5MEK kinase 5c-Jun N-terminal kinaseHepatocellular carcinomaNur771H-Indole-2-carbohydrazideASK1-JNK/P38Inhibitorinhibitorinhibit

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