2. Neuronal Signaling
  3. Amyloid-β
  4. o-Anisidine

o-Anisidine  (Synonyms: o-Methoxyaniline; o-Methoxyphenylamine)

目录号: HY-Y0163
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o-Anisidine 是一种苯酚类化合物，可与 β-淀粉样蛋白 (Aβ1-40) 野生型、Iowa 突变体 D23N 和 Osaka 突变体 ΔE22 相互作用。o-Anisidine 可通过氢键结合 Aβ1-40 的 Leu34 位点。o-Anisidine 可诱导 DNA 损伤生物标志物 γ-H2AX 的形成。o-Anisidine 可导致大鼠膀胱尿路上皮逐渐发生伴轻度炎症的单纯性增生。o-Anisidine 可用于阿尔茨海默病和膀胱癌的相关研究。

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o-Anisidine

o-Anisidine Chemical Structure

CAS No. : 90-04-0

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o-Anisidine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

o-Anisidine is a phenol compound and can interact with amyloid-beta (Aβ1-40) wild-type, Iowa-mutant D23N and Osaka-mutant ΔE22. o-Anisidine can bind to Aβ1-40 Leu34 via hydrogen bonding. o-Anisidine induces formation of γ-H2AX, a biomarker of DNA damage. o-Anisidine causes gradual development of simple hyperplasia of rat urinary bladder urothelium with slight inflammation. o-Anisidine can be used for the researches of Alzheimer's disease and bladder cancer[1][2].

体外研究
(In Vitro)

o-Anisidine (Compound 2-aminoanisole) 可与野生型 Aβ1-40、Iowa 突变体 D23N 及 Osaka 突变体 ΔE22 发生相互作用， 其 Ki 值为 3.67，7.5 和 4.29 mM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

o-Anisidine 相关抗体:
体内研究
(In Vivo)

o-Anisidine (0.3-1.0%；饮食给药；每日；持续 4 周) 可在大鼠膀胱上皮中诱导时间依赖性的单纯性增生及持续性 γ-H2AX 形成，提示存在可能与膀胱癌发生相关的 DNA 损伤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male-specific pathogen-free rats (F344/DuCrl-
Crlj, 5 weeks old)[2]
Dosage: 0.3%; 1.0%
Administration: diet; daily; 4 weeks
Result: Detected simple hyperplasia of the bladder urothelium from week 1, progressing through week 4, with slight inflammation in the 1.0% group。
Increased γ-H2AX-positive bladder epithelial cells significantly in a time-dependent manner from day 2 to week 4, and remained significantly elevated 2 weeks post-recovery in the 1.0% group.
Observed no apparent bladder lesions or increases in γ-H2AX formation in the 0.3% group.
分子量

123.15

Formula

C7H9NO
CAS 号
性状

液体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献

o-Anisidine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

o-Anisidine90-04-0o-Methoxyaniline o-MethoxyphenylamineAmyloid-ββ-amyloid peptideAβAbetabladder carcinogenesisLeu34alzheimer's diseasebladder cancerγ-H2AXAβ1-40Inhibitorinhibitorinhibit

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