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  3. O-Demethylrotenone

O-Demethylrotenone 是鱼藤酮 (HY-B1756) 衍生物及鱼藤酮的光解产物,可引起急性腹腔注射毒性。O-Demethylrotenone 在 Mus musculus 中的急性腹腔注射 LD50 为 8.0 mg/kg。

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O-Demethylrotenone

O-Demethylrotenone Chemical Structure

CAS No. : 36375-21-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

O-Demethylrotenone is a rotenone (HY-B1756) derivative and a photodegradation product of rotenone that induces acute intraperitoneal toxicity. The acute intraperitoneal LD50 of O-Demethylrotenone in Mus musculus is 8.0 mg/kg[1].

体外研究
(In Vitro)

O-Demethylrotenone 由鱼藤酮经三溴化硼脱甲基反应合成,具有特征性的光谱和物理性质,且可通过甲基化反应转化回鱼藤酮。1 g 鱼藤酮与等摩尔三溴化硼反应,同时加入 12 mL 二氯甲烷,在 -10°C 下反应 2 分钟即可获得 O-Demethylrotenone[1]
O-Demethylrotenone 是鱼藤酮在充氧甲醇溶液中经紫外线照射后发生光分解反应生成的中性产物。反应条件:将 1 g 鱼藤酮溶于 600 mL甲醇中;在通入氧气的情况下进行紫外线照射 2 小时[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

O-Demethylrotenone (8.0 mg/kg; i.p.; 单次) 对成年雄性小白鼠的 24 小时腹腔注射 LD50 为 8.0 mg/kg[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: white mice (adult male)[1]
Dosage: 8.0 mg/kg
Administration: i.p.; single dose
Result: Determined a 24-hour intraperitoneal LD50 of 8.0 mg/kg.
分子量

380.39

Formula

C22H20O6

CAS 号
中文名称

3-去甲鱼藤酮

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
O-Demethylrotenone
目录号:
HY-N11732
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