2. Neuronal Signaling
  3. OLIG2
  4. OLIG2-IN-1

OLIG2-IN-1 是一种强效且选择性的少突胶质细胞转录因子 2 (OLIG2) 抑制剂。OLIG2-IN-1 能直接且剂量依赖性地下调细胞核中 OLIG2 的水平，IC50 值为 0.88 μM。OLIG2-IN-1 在 U87 和 U251 细胞中表现出强大的抗增殖活性，其 IC50 值分别为 7.02 μM 和 6.43 μM。OLIG2-IN-1 可用于癌症研究，如多形性胶质母细胞瘤。

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OLIG2-IN-1

OLIG2-IN-1 Chemical Structure

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OLIG2-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme[1].

体外研究
(In Vitro)

OLIG2-IN-1 (Compound B01) (10 μM, 12 h) 在 U87 细胞中对核内 OLIG2 蛋白水平的降低作用最显著，能够降低 75.87%[1]。
OLIG2-IN-1 在 LN18 和 C6 细胞中表现出抗增殖活性，其 IC50 值分别为 8.88 μM 和 6.02 μM[1]。
OLIG2-IN-1 (5 μM, 10 days) 可显著抑制 U87 细胞的集落形成[1]。
OLIG2-IN-1 (0.02-10 μM, 12 h) 以剂量依赖性方式降低 U87 和 U251 细胞中核内 OLIG2 蛋白的水平[1]。
OLIG2-IN-1 可保护U87 细胞和 U251 细胞中 OLIG2 免受热诱导的变性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OLIG2-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: U87 and U251 cells
Concentration: 0.02, 0.04, 0.08, 0.16, 0.31, 0.62, 1.25, 2.5, 5, 7.5 and 10 μM
Incubation Time: 12 h
Result: Reduced nuclear OLIG2 protein levels in a clear dose-dependent manner.
体内研究
(In Vivo)

OLIG2-IN-1 (Compound B01) (50 mg/kg，腹腔注射，每两天一次，持续 21 天) 在 U87 异种移植小鼠模型中与 Temozolomide (HY-17364) 联合使用时可抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: U87 xenograft mice models[1]
Dosage: 50 mg/kg, companied with 39 mg/kg of Temozolomide (HY-17364)
Administration: Intraperitoneally injection, every other day for 21 days
Result: Had stable body weights.
Reduced tumor volumes to 44.6 % and weight to 50.0 %.
Downregulated OLIG2 expression.
分子量

298.13

Formula

C11H9Cl2N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OLIG2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OLIG2-IN-1OLIG2Oligodendrocyte Transcription Factor 2Oligodendrocyte transcription factorU87U251Glioblastoma multiformeInhibitorinhibitorinhibit

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