2. Apoptosis TGF-beta/Smad NF-κB Immunology/Inflammation
  3. Apoptosis TGF-β Receptor NF-κB Interleukin Related IFNAR TNF Receptor
  4. Omtriptolide sodium

Omtriptolide sodium (PG490-88Na) 是 Triptolide (HY-32735) 的衍生物。Omtriptolide sodium 具有显著的免疫抑制、抗纤维化和抗炎特性。Omtriptolide sodium 作用机制多样，包括抑制 T 细胞活化与增殖、诱导 T 细胞凋亡 (apoptosis)、阻断成纤维细胞成熟/增殖、抑 TGF-β mRNA表达，以及通过阻断 NF-κB 等转录因子抑制促炎细胞因子 (如 IL-2、IFN-γ、TNF-α) 的生成。Omtriptolide sodium 可用于研究闭塞性气道疾病、肺纤维化和移植物抗宿主病。

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Omtriptolide sodium

Omtriptolide sodium Chemical Structure

CAS No. : 195883-09-1

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Omtriptolide sodium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Omtriptolide sodium (PG490-88Na) is a derivative of Triptolide (HY-32735). Omtriptolide sodium exhibits significant immunosuppressive, anti-fibrotic and anti-inflammatory properties. The mechanism of action of Omtriptolide sodium is diverse, including inhibiting T cell activation and proliferation, inducing T cell apoptosis (apoptosis), blocking fibroblast maturation/proliferation, inhibiting TGF-β mRNA expression, and suppressing pro-inflammatory cytokines (such as IL-2, IFN-γ, TNF-α) by blocking transcription factors such as NF-κB. Omtriptolide sodium can be used for research on obstructive airway diseases, pulmonary fibrosis and graft-versus-host disease[1][2][3][4].

分子量

482.46

Formula

C24H27NaO9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Omtriptolide sodium 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Omtriptolide195883-09-1PG 490-88NaApoptosisTGF-β ReceptorNF-κBInterleukin RelatedIFNARTNF ReceptorTransforming growth factor beta receptorsNuclear factor-κBNuclear factor-kappaBILInterferon-α/β receptorInterferon-alpha/beta receptor Tumor Necrosis Factor ReceptorTNFRPG490-88triptolideimmunosuppressantobliterative airway diseasepulmonary fibrosisgraft-versus-host diseaseTGF-β inhibitionT-cell apoptosisInhibitorinhibitorinhibit

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