2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. OP-1690

OP-1690 是一种完全雌激素受体 (ERα) 拮抗剂 (CERAN)，其在碱性磷酸酶 (AP) 活性测定和 TR-FRET 测定的 pIC50 分别为 7.5 和 7.9。OP-1690 通过诱导 ERα 四聚化来调控受体功能，能有效诱导 ERα 降解，抑制靶基因转录，但抗增殖效力较低。OP-1690 可用于研究乳腺癌。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

OP-1690

OP-1690 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

OP-1690 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OP-1690 is a complete estrogen receptor (ERα) antagonist (CERAN), with pIC50 values of 7.5 and 7.9 in alkaline phosphatase (AP) activity assay and TR-FRET assay, respectively. OP-1690 modulates receptor function by inducing ERα tetramerization, effectively induces ERα degradation, inhibits target gene transcription, but exhibits low antiproliferative potency. OP-1690 can be used for breast cancer research[1].

IC50 & Target[1]

ERα

7.5 (pIC50)

体外研究
(In Vitro)

OP-1690 (7 d) 抑制 MCF7 和 CAMA-1 细胞增殖，其 pIC50 分别为 6 和 5.9，低于Fulvestrant (HY-13636) 和 RAD1901 (HY-19822)。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OP-1690 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Tmax Cmax T1/2 AUC0-last AUC0-∞ CL Vss F
Mice[1] 1 mg/kg i.v. 0.08 h 406 ng/mL 5.6 h 291 ng·h/mL 298 ng·h/mL 55.9 mL/min/kg 12.1 L/kg /
Mice[1] 5 mg/kg p.o. 0.25 h 4.95 ng/mL 2.8 h 9.19 ng·h/mL 10.6 ng·h/mL / / 0.7 %
分子量

541.07

Formula

C31H35ClF2N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OP-1690 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OP-1690OP1690OP 1690Estrogen Receptor/ERRERα ligand binding domainestrogen receptor-positive breast cancerestrogen receptor alphacomplete estrogen receptor antagonistestrogen receptor-positive breast cancersInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
OP-1690
目录号：
HY-181345
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z