2. Cytoskeleton
  3. Dynamin
  4. Opitor-0

Opitor-0 是一种强效且选择性的线粒体动力相关蛋白视神经萎缩蛋白 1 (OPA1) 鸟苷三磷酸酶 (GTPase) 抑制剂，其 IC50 值为 3 μM。Opitor-0 可诱导线粒体碎片化和嵴重塑，破坏 OPA1 寡聚物的稳定性，并显著促进细胞色素 c 的释放，诱导凋亡 (apoptosis)。Opitor-0 与 Bcl-2 抑制剂 ABT-737 (HY-50907) 和 Venetoclax (HY-15531) 具有协同抗肿瘤作用。Opitor-0 可用于对 Bcl-2 抑制剂耐药的恶性肿瘤研究，例如三阴性乳腺癌 (TNBC)。

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Opitor-0

Opitor-0 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1800
3 - 5 周
5 mg ￥3870
3 - 5 周
10 mg 询价 3 - 5 周
25 mg 询价 3 - 5 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Opitor-0 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Opitor-0 is a potent and selective inhibitor of mitochondrial dynamin-related protein Optic Atrophy 1 (OPA1) guanosine triphosphatase (GTPase) with an IC50 of 3 μM. Opitor-0 can induce fragmentation of mitochondria and remodeling of cristae, disrupt the stability of OPA1 oligomers, and significantly enhance the release of cytochrome c and induce apoptosis. Opitor-0 has a synergistic antitumor effect with Bcl-2 inhibitors, such as ABT-737 (HY-50907) and Venetoclax (HY-15531). Opitor-0 can be used for the research of malignant tumors that are resistant to Bcl-2 inhibitors, such as triple-negative breast cancer (TNBC)[1].

分子量

519.62

Formula

C30H25N5O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Opitor-0 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opitor-0Opitor0Opitor 0DynaminInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-177306
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