2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. NADPH Oxidase Reactive Oxygen Species (ROS)
  4. Orazipone

Orazipone (OR 1384) 是一种具有强大抗炎特性的小分子免疫调节剂。Orazipone 通过形成可逆的硫醇结合物，与细胞内信号蛋白和谷胱甘肽的硫醇基团结合，发挥其免疫调节作用。Orazipone 抑制中性粒细胞活化、单核细胞、T 淋巴细胞和肥大细胞的细胞因子产生和局部血小板聚集。Orazipone 抑制 NADPH 氧化酶活性减少 ROS 产生。Orazipone 在肠道辐射损伤中具有保护作用。

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Orazipone

Orazipone Chemical Structure

CAS No. : 137109-78-5

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Orazipone 相关抗体

Top Publications Citing Use of Products

查看 NADPH Oxidase 亚型特异性产品:

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NOX1 NOX2 NOX4 NOX5 DUOX1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Orazipone (OR 1384) is a small molecule immunomodulator with strong anti-inflammatory properties. Orazipone exerts its immunomodulatory effect by forming reversible thiol complexes, which bind to intracellular signaling proteins and the thiol groups of glutathione. Orazipone inhibits the activation of neutrophils, monocytes, T lymphocytes, and mast cells, as well as the production of cytokines and local platelet aggregation. Orazipone reduces NADPH oxidase activity and thereby decreases ROS production. Orazipone has a protective effect in intestinal radiation injury[1].

分子量

266.31

Formula

C13H14O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Orazipone 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orazipone137109-78-5OR 1384OR1384OR-1384NADPH OxidaseReactive Oxygen Species (ROS)NOXRadiation injuriesDisaster planningIntestinesImmunomodulationHSP90 inhibitorsClinical trialsCancer therapeuticsBiomarkersInhibitorinhibitorinhibit

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