2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. OV329 hydrochloride

OV329 hydrochloride 是一种强效的 GABA 氨基转移酶灭活剂。OV329 hydrochloride 是 Vigabatrin (HY-15399) 的类似物。OV329 hydrochloride 可提高大脑中 GABA 水平，并阻断异常的脑内过度兴奋。OV329 hydrochloride 具有抗惊厥和抗癫痫活性。OV329 hydrochloride 可用于神经系统疾病的研究，如癫痫发作。

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OV329 hydrochloride

OV329 hydrochloride Chemical Structure

CAS No. : 2093928-29-9

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规格 价格 是否有货 数量
5 mg ￥2465
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10 mg ￥3910
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Other Forms of OV329 hydrochloride:

OV329 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OV329 hydrochloride is a potent GABA aminotransferase inactivator. OV329 hydrochloride is a Vigabatrin (HY-15399) analogue. OV329 hydrochloride can increase brain GABA levels and block abnormal intracerebral hyperexcitability. OV329 hydrochloride exhibits anticonvulsant and antiepileptic activities. OV329 hydrochloride can be used for the research of neurological disease, such as seizure[1].

体内研究
(In Vivo)

OV329 hydrochloride (5-40 mg/kg，腹腔注射) 在戊四氮 (pentylenetetrazole) 诱导的癫痫发作大鼠中显示出抗惊厥作用[1]。
OV329 hydrochloride (30-40 mg/kg，腹腔注射) 可提高杏仁核点燃大鼠的后放电阈值[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pentylenetetrazole-induced seizuring Wistar Unilever rats[1]
Dosage: 5, 20 and 40 mg/kg
Administration: Intraperitoneally injection
Result: Increased myoclonic seizure threshold from the 15.8 to 33.1 mg/kg at 40 mg/kg.
Increased clonic seizure threshold from the 19.5 to 40.98 mg/kg at 40 mg/kg.
Showed the EC50 for myoclonic seizures is 25.83 mg/kg and for clonic seizures is 20.8 mg/kg.
Showed the responder rate of rats reaches 100% at the dose of 40 mg/kg.
分子量

211.59

Formula

C7H8ClF2NO2
CAS 号
性状

粉末

颜色

Off-white to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

OV329 hydrochloride 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OV3292093928-29-9OV 329OV-329GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorPentylenetetrazolethresholdmyoclonic seizureclonic seizureInhibitorinhibitorinhibit

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产品名称：
OV329 hydrochloride
目录号：
HY-179215
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