2. 疾病领域
  3. 感染
  4. MeV-IN-1

MeV-IN-1 (OX-1) 是一种特异性抑制麻疹病毒 (MeV) 进入细胞的抑制剂，其 IC50 值为 100 μM。MeV-IN-1 对活体 MeV-Edm 病毒的 IC50 值为 55 μM。MeV-IN-1 可有效抑制感染灶的形成。MeV-IN-1 几乎没有细胞毒性。MeV-IN-1 可有效抑制在表达 MV-H 和 MV-F 蛋白的细胞中 R18 的重新分布，从而阻止细胞膜融合。

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MeV-IN-1

MeV-IN-1 Chemical Structure

CAS No. : 313527-44-5

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MeV-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MeV-IN-1 (OX-1) is an inhibitor of specific specific Measles virus (MeV) entry with an IC50 of 100 M. MeV-IN-1 has an IC50 of 55 M against live MeV-Edm. MeV-IN-1 efficiently suppresses the formation of infectious centers. MeV-IN-1 exhibits negligible cytotoxicity. MeV-IN-1 potently suppresses R18 redistribution in MV-H- and MV-F-expressing cells, preventing membrane merging[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero CC50
> 600 μM
Compound: 1a
Cytotoxicity against Vero-CD150w cells
Cytotoxicity against Vero-CD150w cells
[PMID: 16913698]
Vero EC50
0.4 μM
Compound: 24, OX-1
Inhibition of Measles virus hemagglutininin/F-mediated cell-cell fusion expressed in african green monkey Vero cells after 24 hrs relative to untreated control
Inhibition of Measles virus hemagglutininin/F-mediated cell-cell fusion expressed in african green monkey Vero cells after 24 hrs relative to untreated control
[PMID: 19499921]
Vero EC50
8 μM
Compound: 24, OX-1
Cytotoxicity against african green monkey Vero cells after 16 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 16 hrs by MTT assay
[PMID: 19499921]
Vero EC50
> 8 μM
Compound: 24, OX-1
Inhibition of Nipah virus glycoprotein G/F-mediated cell-cell fusion expressed in african green monkey Vero cells after 24 hrs relative to untreated control
Inhibition of Nipah virus glycoprotein G/F-mediated cell-cell fusion expressed in african green monkey Vero cells after 24 hrs relative to untreated control
[PMID: 19499921]
分子量

224.26

Formula

C14H12N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MeV-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MeV-IN-1313527-44-5OX-1OX1OX 1OthersInhibitorinhibitorinhibit

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