p-F-HHSiD hydrochloride  (Synonyms: p-Fluorohexahydrosiladifenidol hydrochloride)

p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a potent and selective M3 mAChR antagonist. p-F-HHSiD hydrochloride has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD hydrochloride can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes^{[1][2][3][4][5][6]}.

p-F-HHSiD (30 nM-10 μM, 60-180 mins) 对豚鼠气管组织中 M₃ 受体介导的收缩反应具有拮抗作用^[1]。
p-F-HHSiD (100 μM, 5 days) 通过选择性阻断 M₃ 毒蕈碱受体，将 H508 人结肠癌细胞的基础增殖抑制 40%^[2]。
p-F-HHSiD (0.03-3 μM) 可显著抑制分离的小鼠左心房中乙酰胆碱 (Ach) 引起的正性肌力反应阶段^[3]。
p-F-HHSiD (0.1 nM-100 μM, 90 mins) 在来自额叶皮质 (阿尔茨海默病大脑) 的 P2 粗制突触体组分中，对毒蕈碱受体表现出单一类别的结合位点^[4]。
p-F-HHSiD (1 μM, 2 h) 可显著抑制乙酰胆碱 (Ach) 诱导的分离的人脐静脉 (妊娠期糖尿病) 收缩^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

386.02

C₂₀H₃₃ClFNOSi

175615-76-6

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9.  [Content Brief]

  [2]. Cheng K, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G591-7.  [Content Brief]

  [3]. Nishimaru K, et al. Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sci. 2000;66(7):607-15.  [Content Brief]

  [4]. Svensson AL, et al. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res. 1992 Nov 20;596(1-2):142-8.  [Content Brief]

  [5]. He Y, et al. GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep. 2025 Jul 7;15(1):24308.  [Content Brief]

  [6]. Shinoura H, et al. Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):368-71.  [Content Brief]