2. Membrane Transporter/Ion Channel Apoptosis
  3. P-glycoprotein Apoptosis
  4. P-gp-IN-31

P-gp-IN-31 是一种 P-糖蛋白 (P-gp) 抑制剂，其对 KB 细胞和 MDR KBvin 细胞的 IC50 值分别为 0.42 μM 和 0.43 μM。P-gp-IN-31 能够克服 P-gp 介导的药物外排机制，并通过下调 P-gp 表现出附属敏感性。P-gp-IN-31 可抑制细胞增殖、诱导细胞凋亡 (apoptosis) 并将细胞周期阻滞在 G2/M 期。P-gp-IN-31 可用于癌症研究，如多药耐药 (MDR) 恶性肿瘤。

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P-gp-IN-31

P-gp-IN-31 Chemical Structure

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P-gp-IN-31 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P-gp-IN-31 is a P-glycoprotein (P-gp) inhibitor with IC50 values of 0.42 μM for KB cells and 0.43 μM for MDR KBvin cells. P-gp-IN-31 can pass P-gp-mediated drug efflux mechanisms and shows collateral sensitivity via P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis and arrests the cell cycle at G2/M phase. P-gp-IN-31 can be used for the research of cancer, such as multidrug-resistant (MDR) malignancies[1].

体外研究
(In Vitro)

P-gp-IN-31 (Compound 12n) (1-2 μM, 24 h) 可诱导 KB 和 KBvin 细胞凋亡，并将细胞周期阻滞在 G2/M 期[1]。
P-gp-IN-31 (0.1-0.25 μM) 可恢复 KBvin 细胞对紫杉醇 (HY-B0015) 的化学敏感性[1]。
P-gp-IN-31 (0.25 μM, 24 h) 可降低 KBvin 细胞中 P-糖蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

P-gp-IN-31 相关抗体:

Cell Cycle Analysis[1]

Cell Line: KB and KBvin cells
Concentration: 1 and 2 μM
Incubation Time: 24 h
Result: Revealed a considerable increase in the sub-G1 population.
Led to cell accumulation in the G2/M phase.
Upregulated CCNB1 and CCNA2 levels.
Increased levels of cyclin B1 and cyclin A2.
分子量

303.26

Formula

C16H11F2NO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P-gp-IN-31 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp-IN-31P-glycoproteinApoptosisP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243KBKBvinMDRZebrafishInhibitorinhibitorinhibit

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产品名称：
P-gp-IN-31
目录号：
HY-175522
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