2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. p53 Activator 16

p53 Activator 16 (Compound JC16) 是一种 p53 激活剂。p53 Activator 16 对 p53-Y220C 突变癌细胞具有选择性细胞毒性和促凋亡 (apoptosis) 活性，对野生型或 P53 缺失的细胞影响很小。p53 Activator 16 诱导了细胞 p53-Y220C 从突变型到野生型的构象转变，同时伴随着 p53 靶基因的转录激活，且未增加总 p53 蛋白的水平。p53 Activator 16 可用于研究 p53 突变癌症。

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p53 Activator 16

p53 Activator 16 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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p53 Activator 16 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P53 Activator 16 (Compound JC16) is a p53 activator. P53 Activator 16 exhibits selective cytotoxicity and pro-apoptotic (apoptosis) activity towards p53-Y220C mutant cancer cells, while having little effect on wild-type or P53-deficient cells. P53 Activator 16 induces the conformational transition of cell p53-Y220C from the mutant form to the wild-type form, accompanied by the transcriptional activation of p53 target genes, without increasing the overall level of p53 protein. P53 Activator 16 can be used for the study of p53 mutant cancers[1].

分子量

299.33

Formula

C15H17N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

p53 Activator 16 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 Activator 16MDM-2/p53Apoptosisindazole derivativessmall molecule reactivatorsconformational shiftselective cytotoxicityapoptosistranscriptional activationcellular thermal stabilityInhibitorinhibitorinhibit

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目录号：
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