2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR PGC-1α
  4. PA-082

PA-082 是一种选择性 PPAR-γ 调节剂，表现为部分激动剂。PA-082 可诱导部分招募 SRC1、TIF2 和 SRC3，并实现对 PGC1-α 的完全招募至 PPAR-γ 配体结合域。PA-082 能抑制新生脂肪生成过程中的甘油三酯积累，并拮抗 Rosiglitazone (HY-17386) 诱导的脂质积累。PA-082 可增强脂肪细胞中胰岛素刺激的葡萄糖摄取，并保护细胞免受 TNFα 诱导的胰岛素抵抗。PA-082 可用于 2 型糖尿病的研究。

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PA-082

PA-082 Chemical Structure

CAS No. : 95520-87-9

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PA-082 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PA-082 is a selective PPAR-γ modulator that functions as a partial agonist. PA-082 causes partial recruitment of SRC1, TIF2, SRC3 and full recruitment of PGC1-α to PPAR-γ ligand-binding domain. PA-082 prevents triglyceride accumulation during de novo adipogenesis and antagonizes Rosiglitazone (HY-17386)-induced lipid accumulation. PA-082 potentiates insulin-stimulated glucose uptake in adipocytes and protects against TNFα-induced insulin resistance. PA-082 can be used for the research of type 2 diabetes[1].

IC50 & Target

PPAR-γ

 

体外研究
(In Vitro)

PA-082 与 PPAR LBD 结合口袋中由螺旋 3、5 和 7 形成的区域结合，而不与螺旋 12 相互作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PA-082 相关抗体:
分子量

542.68

Formula

C33H38N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PA-082 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PA-08295520-87-9PA082PA 082PPARPGC-1αPeroxisome proliferator-activated receptorsPPARγ coactivator-1αPPAR-γde novo adipogenesisperoxisome proliferator-activated receptor γrosiglitazone-induced lipid accumulationSRC3SRC1PGC1-αTIF2ligand-binding domaintriglyceride accumulationInhibitorinhibitorinhibit

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产品名称：
PA-082
目录号：
HY-180398
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