2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR Calcium Channel
  4. PAM-2

PAM-2 是一种强效、口服有效、可穿透血脑屏障的选择性 α7 nAChR 正向变构调节剂 (human α7 nAChR EC50：39 μM，rat α7 nAChR EC50：12 μM)，具有抗痛觉过敏和抗炎活性。PAM-2 对 α9α10 nAChR (IC50 = 174 μM) 和 CaV2.2 通道 (IC50 = 89 μM) 表现出选择性。PAM-2 通过增强 α7 nAChR 活性，减轻 Streptozotocin (STZ) (HY-13753) 和 Oxaliplatin (HY-17371) 诱导的小鼠神经病理性疼痛。PAM-2 可用于神经病理性疼痛的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PAM-2

PAM-2 Chemical Structure

CAS No. : 1426293-61-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PAM-2 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAM-2 is a potent, orally active, CNS-penetrant selective α7 nAChR positive allosteric modulator (human α7 nAChR EC50: 39 μM, rat α7 nAChR EC50: 12 μM) with anti-nociceptive and anti-inflammatory activity. PAM-2 exhibits selectivity over α9α10 nAChR (IC50 = 174 μM) and CaV2.2 channel (IC50 = 89 μM). PAM-2 decreases Streptozotocin (STZ) (HY-13753)- and Oxaliplatin (HY-17371)-inducned nuroparhic pain in mice by α7 nAChR potentiation. PAM-2 can be used for the research of neuropathic pain[1].

IC50 & Target[1]

human α7 nAChR

39 μM (EC50)

rat α7 nAChR

12 μM (EC50)

CaV2.2

89 μM (IC50)

α9α10 nAChR

174 μM (IC50)

体外研究
(In Vitro)

PAM-2 (0.3 μM-1 mM；5 分钟) 以浓度依赖的方式增强 Xenopus 卵母细胞中乙酰胆碱 (30 μM) 激活的 α7 nAChRs 活性[1]。
PAM-2 (0.3 μM-1 mM；2 分钟) 以浓度依赖性且电压无关的方式抑制非洲爪蟾卵母细胞中 rα9α10 nAChRs 对乙酰胆碱 (10 μM) 诱发的电流[1]。
PAM-2 (0.3 μM-1 mM) 在 HEK293 细胞中抑制 Cav2.2 通道介导的 Ba2+电流，而不影响 G 蛋白偶联的 GABABR[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAM-2 相关抗体:
体内研究
(In Vivo)

PAM-2 (1 和 3 mg/kg；口服；在 STZ 后第 15 天单次给药) 可减轻小鼠的 STZ 和 Oxaliplatin 诱导的神经病理性疼痛[1]。
PAM-2 (1 mg/kg；口服；与 Oxaliplatin 联合给药 14 天；在最后一次联合给药后 30 分钟额外给药一次) PAM-2 与 Oxaliplatin 共同给药 14 天可预防疼痛，追加给药可提高痛阈[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 albino mice (2-3 months old) intraperitonealy injected with STZ (100 mg/kg)[1]
Dosage: 1, 3 mg/kg
Administration: p.o.; single dose on day 15 post-STZ
Result: Significantly decreased neuropathic pain between 15 and 45 min at 3 mg/kg, 45 min, with complete reversal at 30 min.
Showed no effect at 1 mg/kg.
Animal Model: Male CD-1 albino mice (2-3 months old) intraperitonealy injected with Oxaliplatin (2.4 mg/kg) on days 1-3, 6-10, and 13-14[1]
Dosage: 1, 3 mg/kg
Administration: p.o.; single dose on day 15 post-Oxaliplatin
Result: Significantly decreased neuropathic pain from 15 to 45 minutes after administration, with peak reversal at 30 min at 3 mg/kg.
Showed no effect at 1 mg/kg.
Animal Model: Male CD-1 albino mice (2-3 months old) intraperitonealy injected with Oxaliplatin (2.4 mg/kg) on days 1-3, 6-10, and 13-14[1]
Dosage: 1 mg/kg
Administration: p.o; coadministered with oxaliplatin schedule for 14 days; and an extra dose 30 min post last co-treatment
Result: Prevented pain establishment by day 14.
An additional administration on the test day produced greater pain reversal within 0-30 min.
分子量

227.26

Formula

C14H13NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAM-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAM-21426293-61-9PAM2PAM 2nAChRCalcium ChannelNicotinic acetylcholine receptorsCa2+ channelsCa channelshuman α7 nAChRsCD-1 albino micerat α7 nAChRshCa_V2.2 channelsoxaliplatin-induced neuropathic painSTZ-induced neuropathic painα7 nicotinic acetylcholine receptoranti-nociceptive pain activityα7 nAChRrα9α10 nAChRsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PAM-2
目录号：
HY-180400
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z