2. PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Apoptosis
  3. PI3K mTOR Anaplastic lymphoma kinase (ALK) DNA-PK Apoptosis
  4. Panulisib

Panulisib  (Synonyms: P7170; AK151761)

目录号: HY-16769
产品使用指南 技术支持

Panulisib (P7170; AK151761) 是一种口服有效的 PI3K (IC50 = 2.2 nM) 和 mTOR (IC50 = 4.4 nM) 抑制剂。Panulisib 抑制 ALK1 和 DNA-PK，这两种酶分别参与血管生成和 DNA 修复，IC50 分别为 47 nM 和 1.5 nM。Panulisib 抑制细胞增殖和凋亡 (apoptosis)。Panulisib 可用于研究乳腺癌和非小细胞肺癌。

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Panulisib

Panulisib Chemical Structure

CAS No. : 1356033-60-7

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Panulisib 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Panulisib (P7170; AK151761) is an orally active inhibitor of PI3K (IC50 = 2.2 nM) and mTOR (IC50 = 4.4 nM). Panulisib inhibits ALK1 and DNA-PK, two enzymes that respectively participate in angiogenesis and DNA repair, with IC50 values of 47 nM and 1.5 nM respectively. Panulisib inhibits cell proliferation and apoptosis. Panulisib can be used for research on breast cancer and non-small cell lung cancer[1][2][3].

分子量

527.50

Formula

C27H20F3N9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Panulisib 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Panulisib1356033-60-7P7170 AK151761P 7170P-7170AK151761AK 151761AK-151761PI3KmTORAnaplastic lymphoma kinase (ALK)DNA-PKApoptosisPhosphoinositide 3-kinaseMammalian target of RapamycinAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246DNA-dependent protein kinasemTOR inhibitorALK1 inhibitorPI3K/mTOR pathwayanticancer therapyangiogenesis inhibitionkinase inhibitortargeted therapyxenograft modelsclinical developmentInhibitorinhibitorinhibit

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