2. Metabolic Enzyme/Protease TGF-beta/Smad Stem Cell/Wnt
  3. Phosphodiesterase (PDE) PKA
  4. PDE2-IN-1

PDE2-IN-1 是一种强效的口服有效的 PDE2 抑制剂，其 IC50 为 0.6 μM，表现出神经保护作用。PDE2-IN-1 通过抑制 PDE2 调节 PKA/CREB/BDNF 信号通路。PDE2-IN-1 可改善 okadai acid (OKA) 诱导的阿尔茨海默病 (AD) 小鼠模型的记忆缺陷和认知障碍。PDE2-IN-1 可用于阿尔茨海默病的研究。

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PDE2-IN-1

PDE2-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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规格 是否有货
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PDE2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

查看 PKA 亚型特异性产品:

查看所有亚型
PKA PKAR PKACα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDE2-IN-1 is a potent and orally active PDE2 inhibitor with an IC50 of 0.6 μM, demonstrating neuroprotective effects. PDE2-IN-1 modulates the PKA/CREB/BDNF signaling pathway by inhibiting PDE2. PDE2-IN-1 improves memory deficits and cognitive impairment in an okadai acid (OKA)-induced Alzheimer’s disease (AD) mouse model. PDE2-IN-1 can be used for the research of AD[1].

IC50 & Target[1]

PDE2

0.6 μM (IC50)

体外研究
(In Vitro)

PDE2-IN-1 (compound 14c) (0-50 μM；24 小时) 对神经元细胞 (U251、SY5Y 和 HMC3 细胞) 无细胞毒性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PDE2-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: U251, SY5Y, and HMC3 cell lines
Concentration: 0, 1.5625, 3.125, 6.25, 12.5, 25, 50 μM
Incubation Time: 24 h
Result: Showed no effects on U251, SY5Y, and HMC3 cell survival rates.
体内研究
(In Vivo)

PDE2-IN-1 (10 和 30 mg/kg，腹腔注射，每日一次，持续 14 天) 可改善 OKA 诱导的阿尔茨海默病 (AD) 小鼠模型的记忆缺陷和认知障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (20-30 g) bilateral intracerebroventricularly injected with OKA[1]
Dosage: 10 and 30 mg/kg
Administration: i.p., daily for 14 days
Result: Had a negligible effect on the mean daily bodyweight profile in OKA-induced AD mice.
Showed no obvious changes of the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), carbamide (UREA), creatinine (CREA) and AST/ALT ratio in OKA-induced AD group and different doses group.
Led to minimal injury to hippocampal neurons.
Showed beneficial effects to ameliorate the memory and cognitive impairment in OKA-induced AD mice.
Ameliorated OKA-induced memory and cognitive impairment via PKA/CREB/BDNF pathway.
Alleviated synaptic impairments in OKA-induced AD mice.
分子量

396.36

Formula

C18H19F3N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDE2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE2-IN-1Phosphodiesterase (PDE)PKAProtein kinase A2456-Tetrahydro-7H-pyrazolo[34-c]pyridine-7-onePDE2 inhibitorsInhibitorinhibitorinhibit

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