2. GPCR/G Protein PI3K/Akt/mTOR Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Autophagy Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. GCGR PI3K Akt Reactive Oxygen Species (ROS) Autophagy Interleukin Related Sirtuin AMPK Apoptosis
  4. Pegloxenatide

Pegloxenatide  (Synonyms: Polyethylene glycol loxenatide; PEX 168)

目录号: HY-P3491 纯度: 90.00%
COA 产品使用指南 技术支持

Pegloxenatide (Polyethylene glycol loxenatide) 是一种长效的胰高血糖素样肽-1 受体 (GLP-1RA) 激动剂。Pegloxenatide 具有降血糖、降血脂、改善体重、抗炎、促伤口愈合、保肝、保护心脏等多种活性。Pegloxenatide 可用于 2 型糖尿病及其多种并发症的研究。

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Pegloxenatide

Pegloxenatide Chemical Structure

CAS No. : 2420483-82-3

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规格 价格 是否有货 数量
250 μg ￥1850
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500 μg ￥3000
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Pegloxenatide 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pegloxenatide (Polyethylene glycol loxenatide) is a long-acting glucagon-like peptide-1 receptor (GLP-1RA) agonist. Pegloxenatide has various activities such as lowering blood glucose, lowering blood lipids, improving body weight, anti-inflammation, promoting wound healing, protecting the liver, and protecting the heart. Pegloxenatide can be used in the research of type 2 diabetes and its multiple complications[1][2][3][4].

体外研究
(In Vitro)

Pegloxenatide (100-200 nM；24 h) 在高糖处理的 HepG2 细胞中，可激活 PI3K/AKT 通路，而 PI3K 抑制剂 LY294002 (HY-10108) 能抑制其激活作用[1]。
Pegloxenatide (250 nM；24 h) 在高糖和 Palmitic acid (HY-N0830) 处理的人内皮祖细胞中可恢复细胞的管形成和迁移能力，增加 NO 生成，减少线粒体 ROS 产生，改善线粒体膜电位和呼吸功能，并恢复自噬流[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pegloxenatide 相关抗体:

Western Blot Analysis[1]

Cell Line: High glucose-treated HepG2 cells
Concentration: 100 and 200 nM
Incubation Time: 24 h
Result: Significantly increased the levels of p-PI3K and p-AKT.
体内研究
(In Vivo)

Pegloxenatide (0.3-1 mg/kg；皮下注射；每 3 天一次；连续 4 周) 在 db/db 小鼠中具有降糖和保肝作用[1]。
Pegloxenatide (0.03 mg/kg/周；腹腔注射；12 周) 在 db/db 小鼠中具有改善葡萄糖代谢，抗炎和加速伤口愈合的活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6-db/db male mice[1]
Dosage: 0.3 and 1 mg/kg
Administration: Subcutaneous injection; once every 3 days; 4 weeks
Result: Significantly reduced body weight and fasting glucose, mincreased glucose tolerance, improved serum and liver biochemical parameters, and attenuated hepatic steatosis and liver and pancreatic tissue damages in db/db mice.
Considerably inhibited oxidative stress, decreased pro-inflammatory factor (TNF-α, IL-6, and MCP-1) levels, increased anti-inflammatory factor IL-10 levels, upregulated Sirt1, p-AMPK, and p-ACC expressions in the Sirt1/AMPK/ACC pathway, promoted GLP-1R expression by inhibiting β-cell apoptosis, and activated the insulin PI3K/AKT pathway to exert hypoglycemic and hepatoprotective effects.
Clinical Trial
Formula

(C₂H₄O)n(C₂H₄O)nC₂₀₆H₃₁₇N₅₅O₆₇S
CAS 号
性状

液体

颜色

Colorless to light yellow

Sequence

PEGn-His-{d-Ala}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-{Nle}-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Gln-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Cys-NH2
Sequence Shortening

PEGn-H-{d-Ala}-EGTFTSDLSKQ-{Nle}-EEEAVRLFIEWLKQGGPSSGAPPPC-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 90.00%

COA (265 KB)

产品使用指南 (1538 KB)
参考文献

Pegloxenatide 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pegloxenatide2420483-82-3Polyethylene glycol loxenatide PEX 168PEX168PEX 168PEX-168GCGRPI3KAktReactive Oxygen Species (ROS)AutophagyInterleukin RelatedSirtuinAMPKApoptosisGlucagon ReceptorPhosphoinositide 3-kinasePKBProtein kinase BILAMP-activated protein kinasepolyethylene glycol loxenatidelong-actingglucagon-like peptide-1 receptortype 2 diabetes mellitus (T2DM)db/db male miceInhibitorinhibitorinhibit

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