2. Membrane Transporter/Ion Channel
  3. BCRP
  4. Pentamethoxymorin

Pentamethoxymorin (MRS923) 作为选择性乳腺癌耐药蛋白 (BCRP/ABCG2) 抑制剂。Pentamethoxymorin 对 BCRP 表现出对 P-gp 和 MRP1 的选择性。Pentamethoxymorin 在 Hoechst 33342 (HY-15559) 检测和 Pheophorbide A (HY-125665) 检测中分别对 MDCK BCRP 细胞表现出 IC50 值 5.98 μM 和 5.94 μM。Pentamethoxymorin 可用于癌症研究。

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Pentamethoxymorin

Pentamethoxymorin Chemical Structure

CAS No. : 7555-80-8

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Pentamethoxymorin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pentamethoxymorin (MRS923) is a selective breast cancer resistance protein (BCRP/ABCG2) inhibitor. Pentamethoxymorin shows selectivity for BCRP over P-gp and MRP1. Pentamethoxymorin inhibits MDCK BCRP cells with IC50 vaues of 5.98 μM and 5.94 μM in Hoechst 33342 (HY-15559) assay and Pheophorbide A (HY-125665) assay, respectively. Pentamethoxymorin can be used for the study of ccancer[1].

体外研究
(In Vitro)

Pentamethoxymorin (compound 11) (0.031-100 µM；30 min-72 h) 可抑制 BCRP 并轻度抑制 P-gp，对 MRP1 无抑制作用且细胞毒性较低 (BCRP 的 IC50 为 5.94-5.98 μM，P-gp 的 IC50 为 27.1 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pentamethoxymorin 相关抗体:
分子量

372.37

Formula

C20H20O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pentamethoxymorin 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentamethoxymorin7555-80-8MRS923MRS 923MRS-923BCRPBreast cancer resistance proteinABCG2P-gp-overexpressing cellsBCRP/ABCG2P-gpMRP1Breast Cancer Resistance ProteinBCRP substratesP-glycoproteinBCRP-expressing cellsMultidrug resistance-associated protein 1MRP1-overexpressing cellsInhibitorinhibitorinhibit

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