2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PF-04827736

PF-04827736 (compound (S)-3) 是一种选择性 PDE1 抑制剂，对 PDE1B，PDE1C 和 PDE1A 的 IC50 值分别为 9.1 nM，38 nM 和 42 nM。PF-04827736 对人 PDE1 的选择性抑制作用强于对其他 10 个超家族成员 (PDE2-PDE11) 的抑制作用。PF-04827736 可用于心血管疾病的研究。

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PF-04827736

PF-04827736 Chemical Structure

CAS No. : 2230054-75-6

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Other Forms of PF-04827736:

PF-04827736 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-04827736 (compound (S)-3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11). PF-04827736 can be used for the study of cardiovascular disease[1].

IC50 & Target[1]

PDE1B

9.1 nM (IC50)

PDE1A

42 nM (IC50)

PDE1C

38 nM (IC50)

分子量

327.39

Formula

C17H21N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-04827736 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-048277362230054-75-6PF04827736PF 04827736Phosphodiesterase (PDE)PDE1BPDE1C and PDE1Acardiovascular diseaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-120195A
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