2. Metabolic Enzyme/Protease
  3. Phosphoglycerate Kinase (PGK)
  4. PGK1-IN-1

PGK1-IN-1 (Compound 6e) 是一种强效且选择性的 PGK1 抑制剂 (IC50：33 nM)。PGK1-IN-1 抑制 PGK1 介导的糖酵解代谢，降低葡萄糖消耗/乳酸生成。PGK1-IN-1 增强 Nrf2 的积累和 HO-1 的表达，并抑制炎症细胞因子 IL-1β 和 IL-6 的转录和蛋白水平。PGK1-IN-1 可改善葡聚糖硫酸钠 (DSS) (HY-116282C) 诱导的小鼠实验性结肠炎。PGK1-IN-1 可用于炎症性肠病 (IBD) 的研究。

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PGK1-IN-1

PGK1-IN-1 Chemical Structure

CAS No. : 3093312-81-0

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PGK1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Phosphoglycerate Kinase (PGK) 亚型特异性产品:

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PGK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor (IC50: 33 nM). PGK1-IN-1 inhibits PGK1-mediated glycolytic metabolism and reduces glucose consumption/lactate production. PGK1-IN-1 enhances Nrf2 accumulation and HO-1 expression, and suppresses the transcription and protein levels of the inflammatory cytokines IL-1β and IL-6. PGK1-IN-1 ameliorates Dextran sulfate sodium (DSS) (HY-116282C)-induced experimental colitis in mice. PGK1-IN-1 can be used for research of inflammatory bowel disease (IBD)[1].

IC50 & Target[1]

PGK1

33 nM (IC50)

分子量

424.50

Formula

C22H28N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PGK1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PGK1-IN-13093312-81-0Phosphoglycerate Kinase (PGK)Phosphoglycerate Kinaseinflammatory bowel diseaseIBDDSSglycolyticInhibitorinhibitorinhibit

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