2. Metabolic Enzyme/Protease
  3. Glutathione S-transferase
  4. Phorone

Phorone  (Synonyms: 佛尔酮; Diisopropylidene acetone)

目录号: HY-W017785
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Phorone (Diisopropylidene acetone) 是一种谷胱甘肽 (GSH) 耗竭剂。Phorone 通过酶促结合 (Glutathione S-transferase) (Km = 0.9 mM) 特异性、可逆性消耗游离 GSH。Phorone 可逆地降低大鼠肝糖皮质激素受体结合和核摄取，且这种效应与 GSH 水平的时间变化相关。Phorone 可用于研究肝毒性。

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Phorone

Phorone Chemical Structure

CAS No. : 504-20-1

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500 mg ￥500
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Phorone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (Km = 0.9 mM). Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.

分子量

138.21

Formula

C9H14O
CAS 号
性状

<28°C 固体,>28°C 液体

颜色

Colorless to light yellow

中文名称

佛尔酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.89%

COA (281 KB) HNMR (116 KB) GC (205 KB)

产品使用指南 (1538 KB)
参考文献

Phorone 相关分类

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Keywords:

Phorone504-20-1Diisopropylidene acetone佛尔酮Glutathione S-transferaseGlutathione transferasesGSTsglutathione depletionhepatotoxicitysynergistic effectsbromobenzeneparacetamolGSH S-transferaseserum transaminasescentrilobular necrosisdose thresholdInhibitorinhibitorinhibit

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