2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3K-IN-41

PI3K-IN-41 (compound 2) 是一种光笼化合物，也是一种具有抗癌特性的光笼 PI3K 抑制剂 (IC50=18.92 nM)。 PI3K-IN-41 有潜力用于精确控制的癌症治疗。 PI3K-IN-41 在紫外线照射下表现出有效的 PI3K 抑制作用，增加抗癌效果。

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PI3K-IN-41

PI3K-IN-41 Chemical Structure

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PI3K-IN-41 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect[1].

IC50 & Target

IC50:18.92 nM (PI3K)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HGC-27 IC50
3.7 nM
Compound: 2
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
HGC-27 IC50
701 nM
Compound: 2
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
MCF7 IC50
428 nM
Compound: 2
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
MCF7 IC50
> 10000 nM
Compound: 2
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
SK-MEL-2 IC50
143 nM
Compound: 2
Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
SK-MEL-2 IC50
2812 nM
Compound: 2
Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
SK-MEL-5 IC50
434 nM
Compound: 2
Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
SK-MEL-5 IC50
6556 nM
Compound: 2
Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
U-87MG ATCC IC50
3257 nM
Compound: 2
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth measured after 72 hrs by CTG assay
[PMID: 37583818]
U-87MG ATCC IC50
52 nM
Compound: 2
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth pre-treated with compound followed by UV irradiation for 5 mins measured after 72 hrs by CTG assay
[PMID: 37583818]
体外研究
(In Vitro)

PI3K-IN-41 (copound 2) (10 nM) 它会降低 HGC-27 细胞中的 AKT 磷酸化，并在紫外线照射 5 分钟、15 分钟和 30 分钟后，(1-10 μM) 抑制 HGC-27 细胞的集落形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-41 相关抗体:
分子量

911.88

Formula

C45H39F2N5O12S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K-IN-41 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-41PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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产品名称：
PI3K-IN-41
目录号：
HY-155730
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