2. Others Autophagy Metabolic Enzyme/Protease Apoptosis
  3. Autophagy Mitophagy Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Apoptosis
  4. Pitavastatin-d4-1 sodium

Pitavastatin-d4-1 sodium  (Synonyms: 匹伐他汀钠盐-d4-1; NK-104-d4-1 sodium)

目录号: HY-B0144AS3
产品使用指南 技术支持

Pitavastatin-d4-1 (NK-104-d4-1) sodium 是氘标记的 Pitavastatin sodium (HY-B0144B)。Pitavastatin (NK-104) sodium 是有效的羟甲基戊二酰-CoA (HMG-CoA) 还原酶抑制剂。Pitavastatin sodium 在 HepG2 细胞中抑制乙酸合成胆固醇的 IC50 为 5.8 nM。Pitavastatin sodium 是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。Pitavastatin sodium 还具有抗动脉粥样硬化、抗哮喘、抗骨关节炎、抗肿瘤、神经保护、肝保护和肾保护作用。

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Pitavastatin-d<sub>4</sub>-1 sodium

Pitavastatin-d4-1 sodium Chemical Structure

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Pitavastatin-d4-1 sodium 的其他形式现货产品:

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Pitavastatin-d4-1 sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pitavastatin-d4-1 (NK-104-d4-1) sodium is the deuterium labeled Pitavastatin sodium (HY-B0144B). Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects[1][2][3][4].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pitavastatin-d4-1 sodium 相关抗体:
分子量

447.47

Formula

C25H19D4FNNaO4
非标记 CAS
中文名称

匹伐他汀钠盐-d4-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pitavastatin-d4-1 sodium 相关分类

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  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pitavastatin-d4-1NK-104-d4-1匹伐他汀钠盐-d4-1AutophagyMitophagyIsotope-Labeled CompoundsHMG-CoA Reductase (HMGCR)ApoptosisMitochondrial AutophagyInhibitorinhibitorinhibit

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