2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. Pyruvate Kinase Apoptosis Endogenous Metabolite Reactive Oxygen Species (ROS)
  4. PKM2-IN-12

PKM2-IN-12 是一种口服有效的 PKM2 抑制剂，其 IC50 为 10 nM。PKM2-IN-12 抑制 COLO-205 细胞增殖和迁移，阻滞细胞周期并诱导细胞凋亡 (apoptosis)。PKM2-IN-12 显著降低了细胞中的乳酸、丙酮酸和 ROS 水平。PKM2-IN-12 在小鼠模型中既直接杀伤癌细胞，又恢复被破坏的肠道微生态平衡。PKM2-IN-12 可用于研究结肠直肠癌。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PKM2-IN-12

PKM2-IN-12 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PKM2-IN-12 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PKM2-IN-12 is an orally active PKM2 inhibitor with an IC50 of 10 nM. PKM2-IN-12 inhibits COLO-205 cell proliferation and migration, arrests the cell cycle, and induces apoptosis. PKM2-IN-12 significantly reduces cellular levels of lactate, pyruvate, and ROS. PKM2-IN-12 directly kills cancer cells and restores disrupted gut microbiota balance in mice model. PKM2-IN-12 can be used to study colorectal cancer[1].
IC50 & Target[1]

PKM2

10 nM (IC50)

体外研究
(In Vitro)

PKM2-IN-12 (Compound 10j) (24 h) 在 COLO-205、CAL-27 和 MCF-7 细胞中表现出显著不同的敏感性，IC50 值分别为 4.21、13.3 和 22.34 μM[1]。
PKM2-IN-12 (4.21 μM, 48 h) 主要通过诱导晚期凋亡杀死 COLO-205 细胞，并将细胞阻滞在 G2 期[1]。
PKM2-IN-12 (4.21 μM) 显著抑制 COLO-205 细胞的迁移能力[1]。
PKM2-IN-12 (4.21 μM, 0-48 h) 显著降低 COLO-205 细胞内乳酸、丙酮酸和活性氧 (ROS) 的水平[1]。
PKM2-IN-12 (4.21 μM, 48 h) 在 COLO-205 细胞中可增加 PKM2 单体和四聚体的表达，但对 PKM1 没有影响[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PKM2-IN-12 相关抗体:
体内研究
(In Vivo)

PKM2-IN-12 (Compound 10j) (50-100 mg/kg，口服，每三天一次，持续 72 天) 能有效抑制结肠炎相关结直肠癌 (CAC) 模型中的肿瘤生长，并逆转小鼠肠道菌群失衡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AOM (HY-111375)/DSS (HY-116282C)-induced colitis-associated colorectal cancer (CAC) model established in BALB/c mice[1]
Dosage: 50, 75 and 100 mg/kg
Administration: Oral administration (p.o,), once every three days for 72 days
Result: Significantly inhibited tumor formation and reduce tumor burden.
Increased the length of the colon, and maintain the stable weight of the mice.
Significantly restored the alpha diversity of the intestinal microbiota in mice.
Reduced the pathological scores of the colon tissue, including inflammatory cell infiltration, epithelial damage and abnormal glandular structure.
分子量

465.35

Formula

C23H14Cl2N4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PKM2-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKM2-IN-12Pyruvate KinaseApoptosisEndogenous MetaboliteReactive Oxygen Species (ROS)Pyruvate Kinase M2COLO-205 cellsmice modelGut Microbiota DysbiosisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PKM2-IN-12
目录号：
HY-178748
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z