2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Endogenous Metabolite Opioid Receptor Leukotriene Receptor
  4. PL265

PL265 是一种口服有效的双脑啡肽酶 (dual enkephalinase) 抑制剂。PL265 是 PL254 的前药，PL254 能同时高效抑制中性内肽酶 (Neprilysin) 和氨肽酶 N (Aminopeptidase N)。PL265 能有效保护并大幅提升疼痛或炎症部位细胞释放的脑啡肽 (如 Met-Enkephalin 和 Leu-Enkephalin) 的局部浓度，从而激活 μ 和 δ 阿片受体 (μ/δ opioid receptor) 产生强效的镇痛作用。PL254 还能抑制白三烯 A4 水解酶 (LTA4H)，这可能通过减少促炎介质白三烯 B4 (LTB4) 的生成，贡献其额外的抗炎效果。PL265 可用于非成瘾性的慢性疼痛研究。

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PL265

PL265 Chemical Structure

CAS No. : 1206514-50-2

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PL265 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PL265 is an orally active dual enkephalinase inhibitor. PL265 is a prodrug of PL254, which can simultaneously and efficiently inhibit neutral endopeptidase (Neprilysin) and Aminopeptidase N. PL265 can effectively protect and significantly increase the local concentration of enkephalins (such as Met-Enkephalin and Leu-Enkephalin) released by cells at the pain or inflammation sites, thereby activating μ and δ opioid receptors to produce a potent analgesic effect. PL254 can also inhibit leukotriene A4 hydrolase (LTA4H), which may contribute to its additional anti-inflammatory effect by reducing the production of pro-inflammatory mediator leukotriene B4 (LTB4). PL265 can be used in non-addictive chronic pain research[1].

分子量

576.58

Formula

C28H37N2O9P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PL265 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PL2651206514-50-2PL 265PL-265Endogenous MetaboliteOpioid ReceptorLeukotriene ReceptorEnkephalinsDENKICorneal painOcular inflammationInhibitorinhibitorinhibit

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