2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein
  3. TRP Channel Cannabinoid Receptor
  4. PQM-244

PQM-244 (Compound 5c) 是一种口服有效的多靶点调节剂，作用于 TRPV1、CB1 和CB2 受体。PQM-244 在神经源性和炎症期均具有显著的外周抗镇痛作用。PQM-244 还具有潜在的抗氧化活性，其清除 DPPH 自由基的 IC50  为  14.15 µM。PQM-244 可用于慢性疼痛和炎症性疾病的研究，例如糖尿病、动脉粥样硬化和阿尔茨海默病。

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PQM-244

PQM-244 Chemical Structure

CAS No. : 316139-50-1

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PQM-244 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PQM-244 (Compound 5c) is an orally active and multi-target modulator of TRPV1 and CB1 and CB2 receptors. PQM-244 has significant peripheral antinociceptive effects on both neurogenic and inflammatory phases. PQM-244 also has potential antioxidant activity with an IC50  of  14.15 µM for radical scavenging DPPH. PQM-244 can be used for chronic pain and inflammatory disease research, such as diabetes, atherosclerosis and Alzheimer’s disease[1].

分子量

298.38

Formula

C18H22N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PQM-244 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PQM-244316139-50-1PQM244PQM 244TRP ChannelCannabinoid ReceptorTransient receptor potential channelsMulti-target modulatorAntinociceptiveAntioxidantInflammatoryDPPHDiabetesAtherosclerosisAlzheimer’s diseaseInhibitorinhibitorinhibit

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