Propanoic acid-¹³C₃  (Synonyms: 丙酸-¹³C₃)

Propanoic acid-¹³C₃ is the ¹³C-labeled Propanoic acid (HY-W020017). Propanoic acid is an orally active short-chain fatty acid. Propanoic acid can be produced by intestinal bacteria from the metabolism of dietary fiber. Propanoic acid increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Propanoic acid also induces Apoptosis and Autophagy. Propanoic acid reduces HSV-1-induced keratitis. Propanoic acid has anticancer effects against glioblastoma. Propanoic acid exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Propanoic acid can be used in the research of spinal cord injury and Alzheimer's disease^{[1][2][3][4][5][6][7]}.

1. 该化合物可作为示踪剂。
2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

77.06

¹³C₃H₆O₂

153474-35-2

79-09-4

丙酸-¹³C₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.   [Content Brief]

  [2]. Filippone A, et al. Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling. Cancers (Basel). 2022 Dec 29;15(1):217.   [Content Brief]

  [3]. Filippone A, et al. The anti-inflammatory and antioxidant effects of sodium propionate. International journal of molecular sciences, 2020, 21(8): 3026.

  [4]. Filippone A, et al. Protective effect of sodium propionate in Aβ1-42-induced neurotoxicity and spinal cord trauma. Neuropharmacology. 2020 Apr;166:107977.   [Content Brief]

  [5]. Park HS, et al. Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacol Sin. 2021 Aug;42(8):1311-1323.   [Content Brief]

  [6]. Sumbria D, et al. Supplementing the Diet with Sodium Propionate Suppresses the Severity of Viral Immuno-inflammatory Lesions. J Virol. 2021 Jan 28;95(4):e02056-20.   [Content Brief]

  [7]. Lang W, et al. Sodium propionate improves cognitive and memory function in mouse models of Alzheimer's disease. Neurosci Lett. 2022 Nov 20;791:136887.   [Content Brief]