2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs Btk
  4. PROTAC BTK Degrader-4

PROTAC BTK Degrader-4 (compound 15) 是一种强效的 PROTAC 布鲁顿酪氨酸激酶 (BTK) 降解剂 (DC50 < 100 nM)，且免疫调节酰亚胺药物 (IMiD) 活性较低 (DC50 = 0.345 μM，Dmax = 27.4%)。PROTAC BTK Degrader-4 可用于BTK 介导的癌症、自身免疫性疾病以及炎症性疾病的相关研究。
(粉色: Btk 配体 (HY-170324)；蓝色: Ligands for E3 Ligase 和 Cereblon E3 连接酶配体；黑色: 连接子)。

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PROTAC BTK Degrader-4

PROTAC BTK Degrader-4 Chemical Structure

CAS No. : 2893795-12-3

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PROTAC BTK Degrader-4 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC BTK Degrader-4 (compound 15) is a potent PROTAC Bruton's tyrosine kinases (BTK) degrader (DC50 < 100 nM) with little immunomodulatory imide drug (IMiD) activity (DC50 = 0.345 μM, Dmax = 27.4%). PROTAC BTK Degrader-4 can be used for cancers, autoimmune diseases, and inflammatory diseases that are mediated by BTK[1]. (Pink: Btk ligand (HY-170324); Blue: Ligands for E3 Ligase and Cereblon E3 ligase ligand; Black: linker).

分子量

806.96

Formula

C42H54N12O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC BTK Degrader-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BTK Degrader-42893795-12-3PROTAC BTK Degrader4PROTAC BTK Degrader 4PROTACsBtkBruton tyrosine kinaseimmunomodulatory imide drugPROTACBTKInhibitorinhibitorinhibit

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