2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs HDAC
  4. PROTAC HDAC8 Degrader-4

PROTAC HDAC8 Degrader-3 (Compound BP6) 是一种高效的、选择性的、低细胞毒性的 HDAC8 PROTAC 降解剂，其 DC50 为 80 nM。PROTAC HDAC8 Degrader-3 对 HDAC8 和 CRBN 的 IC50 为 0.26 和 30 μM。PROTAC HDAC8 Degrader-3 提高了 Ac-SMC3 的水平，能稳定 p53 并增敏靶向试剂 (如 Idasanutlin (HY-15676))，展示了其在联合疗法中的巨大潜力。
(粉色: HDAC8 配体 (HY-15224)；蓝色: Cereblon 配体 (HY-181042)；黑色: 连接子)。

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PROTAC HDAC8 Degrader-4

PROTAC HDAC8 Degrader-4 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

PROTAC HDAC8 Degrader-4 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC HDAC8 Degrader-3 (Compound BP6) is an efficient, selective and low-toxicity HDAC8 PROTAC degrader with a DC50 of 80 nM. PROTAC HDAC8 Degrader-3 exhibits IC50 of PROTAC for HDAC8 and CRBN of 0.26 and 30 μM respectively. PROTAC HDAC8 Degrader-3 increases the level of Ac-SMC3, stabilizes p53 and sensitizes targeted reagents (such as Idasanutlin (HY-15676)), demonstrating its great potential in combination therapy[1]. (Pink: HDAC8 ligand (HY-15224); Blue: Cereblon ligand (HY-181042); Black: linker).

IC50 & Target[1]

HDAC8

80 nM (DC50)

Cereblon

 

分子量

739.77

Formula

C38H41N7O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC HDAC8 Degrader-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC HDAC8 Degrader-4PROTACsHDACHistone deacetylasesprotein degradationphenyl glutarimide (PG)selectivityCRBNp53 stabilizationcombination therapychemical probeInhibitorinhibitorinhibit

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目录号：
HY-181024
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