2. PROTAC MAPK/ERK Pathway Immunology/Inflammation
  3. PROTACs MAP4K Interleukin Related IFNAR
  4. PROTAC HPK1 Degrader-7

PROTAC HPK1 Degrader-7 (compound D02) 是一种高效且选择性的 PROTAC HPK1 降解剂，其 DC50 为 3.07 nM。PROTAC HPK1 Degrader-7 对 GLK 具有选择性。PROTAC HPK1 Degrader-7 以 CRBN 和蛋白酶体依赖的方式诱导 HPK1 降解。PROTAC HPK1 Degrader-7 抑制 SLP-76 磷酸化，并诱导人原代 T 细胞分泌 IL-2 和 IFN-γ。PROTAC HPK1 Degrader-7 可用于免疫研究。
(粉色: MAP4K 和 Ligands for Target Protein for PROTAC 和 HPK1 配体 (HY-179731)；蓝色: Ligands for E3 Ligase 和 Cereblon 配体 (HY-179730)；黑色: 连接子)。

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PROTAC HPK1 Degrader-7

PROTAC HPK1 Degrader-7 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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PROTAC HPK1 Degrader-7 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 MAP4K 亚型特异性产品:

查看所有亚型
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC HPK1 Degrader-7 (compound D02) is a potent and selective PROTAC HPK1 degrader with an DC50 of 3.07 nM. PROTAC HPK1 Degrader-7 exhibits selectivity over GLK. PROTAC HPK1 Degrader-7 induces HPK1 degradation in a CRBN- and proteasome-dependent manner. PROTAC HPK1 Degrader-7 inhibits SLP-76 phosphorylation, induces IL-2 and IFN-γ secretion in human primary T cells. PROTAC HPK1 Degrader-7 can be used for immunology research[1]. (Pink: MAP4K and Ligands for Target Protein for PROTAC and HPK1 ligand (HY-179731); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-179730); Black: linker).

IC50 & Target[1]

HPK1

3.07 nM (DC50)

分子量

844.98

Formula

C46H53FN10O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC HPK1 Degrader-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC HPK1 Degrader-7PROTACsMAP4KInterleukin RelatedIFNARMAPK Kinase Kinase KinaseILInterferon-α/β receptorInterferon-alpha/beta receptorHPK1SLP-76 phosphorylationhuman primary T cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-179727
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