2. PROTAC Stem Cell/Wnt
  3. PROTACs YAP
  4. PROTAC TEAD degrader-2

PROTAC TEAD degrader-2 (Compound 31) 是一种高效的 TEAD1 PROTAC 降解剂，其 DC50 为 0.6 nM。PROTAC TEAD degrader-2 抑制 YAP/TAZ-TEAD 相互作用，其 IC50 为 1.8 nM。PROTAC TEAD degrader-2 对 YAP 依赖性癌细胞具有显著的选择性抑制活性，且有效抑制 YAP 介导的转录活性。PROTAC TEAD degrader-2 可用于研究间皮瘤和胶质瘤。
(粉色: TEAD1 配体 (HY-186022)；蓝色: Cereblon 配体 (HY-122725)；黑色: 连接子 (HY-76199))。

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PROTAC TEAD degrader-2

PROTAC TEAD degrader-2 Chemical Structure

CAS No. : 2918762-17-9

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PROTAC TEAD degrader-2 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 YAP 亚型特异性产品:

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YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC TEAD degrader-2 (Compound 31) is an efficient TEAD1 PROTAC degrader with a DC50 of 0.6 nM. PROTAC TEAD degrader-2 inhibits the YAP/TAZ-TEAD interaction, with a IC50 of 1.8 nM. PROTAC TEAD degrader-2 exhibits significant selective inhibitory activity against YAP-dependent cancer cells and effectively suppresses the transcriptional activity mediated by YAP. PROTAC TEAD degrader-2 can be used for research on mesothelioma and glioma[1]. (Pink: TEAD1 ligand (HY-186022); Blue: Cereblon ligand (HY-122725); Black: linker (HY-76199)).

IC50 & Target[1]

TEAD1

0.6 nM (DC50)

YAP/TAZ-TEAD

1.8 nM (IC50)

分子量

896.42

Formula

C49H52ClF2N5O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC TEAD degrader-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC TEAD degrader-22918762-17-9PROTAC TEAD degrader2PROTAC TEAD degrader 2PROTACsYAPYes-associated proteinYAP/TAZ-TEAD inhibitorPROTACTEAD degradationprotein-protein interactioncancer therapyHippo pathwayubiquitin-proteasome systembiochemical assaycellular proliferationluciferase reporter assayInhibitorinhibitorinhibit

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目录号：
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