2. Anti-infection
  3. Flavivirus Orthopoxvirus SARS-CoV CHIKV Enterovirus
  4. PS1097

PS1097 是一种广谱抗病毒抑制剂，其针对 BVDV RdRp 的 IC50 为 0.64 μM。PS1097 可选择性降低 RTN3 蛋白水平，引起 RTN3 mRNA 部分减少，且对其他内质网驻留蛋白无影响。PS1097 可抑制 卡病毒以及多种以内质网为复制枢纽的病毒的复制。PS1097 可抑制 BVDV RdRp 的酶活性，且对牛病毒性腹泻病毒具有活性。PS1097 可用于寨卡病毒感染、乌苏图病毒感染、西尼罗河病毒感染、COVID-19、柯萨奇病毒 B5 感染、基孔肯雅病毒感染、牛痘病毒感染的相关研究。

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PS1097

PS1097 Chemical Structure

CAS No. : 1822320-58-0

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PS1097 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PS1097 is a broad-spectrum antiviral inhibitor with a BVDV RdRp IC50 of 0.64 μM. PS1097 selectively reduces RTN3 protein levels, causes partial RTN3 mRNA reduction, and leaves other endoplasmic reticulum-resident proteins unaffected. PS1097 inhibits replication of Zika virus and multiple viruses that use the endoplasmic reticulum as a replication hub. PS1097 inhibits BVDV RdRp enzymatic activity and exerts activity against Bovine Viral Diarrhea Virus. PS1097 can be used for the research of zika virus infection, usutu virus infection, west nile virus infection, COVID-19, coxsackie b virus 5 infection, chikungunya virus infection, vaccinia virus infection[1][2][3].

体外研究
(In Vitro)

PS1097 (1.7-100 μM; 48 h) 可强效抑制 Huh-7 细胞中 ZIKV Brazil/2016/INMI1 的复制，其 EC50 为 0.69 μM，选择性指数高达 331.7[1]。
PS1097 (100 μM starting serial dilutions; 48 h most assays) 对多种依赖内质网重塑进行复制的 RNA 和 DNA 病毒具有广谱抗病毒活性，在易感病毒-细胞系组合中的 EC50 值范围为 0.1 至 5.51 μM，且在大多数体系中具有高选择性指数[1]。
PS1097 (0.6-6 μM; 48 h) 可剂量依赖性地抑制 Huh-7 和 Vero E6 细胞中 ZIKV NS5 蛋白的合成，在 6 μM 时观察到最大抑制作用[1]。
PS1097 (6 μM; 48 h) 可在 Huh-7 细胞中强效且选择性地下调 reticulon 3 蛋白水平，同时其对应的 reticulon 3 mRNA 水平出现部分降低[1]。
PS1097 (1.7-100 μM; 48 h) 可强效抑制 Huh-7 细胞中 ZIKVBr 的复制，其 EC50 为 0.69 μM，SI 高达 331.7，提示其具有强抗病毒活性且细胞毒性低[2]。
PS1097 (0.6-6 μM; 48 h) 以剂量依赖方式抑制 Huh-7 和 Vero E6 细胞中 ZIKVBr 的蛋白合成，进而降低病毒滴度[2]。
PS1097 (6 μM; 48 h) 可在 Huh-7 细胞中强效且选择性地下调 RTN3 蛋白水平，同时 RTN3 mRNA 仅出现部分降低，提示该蛋白耗竭存在转录后调控机制[2]。
PS1097 (3-4 days post-viral infection) 可强效抑制 BVDV 诱导的 MDBK 细胞致病变作用，其 EC50 为 1.3 μM，且在浓度高达 100 μM 时无显著细胞毒性[3]。
PS1097 可强效抑制纯化的 BVDV NS5B∆24 聚合酶活性，其 IC50 为 0.64 μM[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PS1097 相关抗体:

Western Blot Analysis[1]

Cell Line: Huh-7 cells, Vero E6 cells
Concentration: 0.6 μM (1× EC50), 3 μM (5× EC50), 6 μM (10× EC50)
Incubation Time: 48 h
Result: Dose-dependently reduced ZIKV NS5 protein levels in both Huh-7 and Vero E6 cells.
Drastically reduced NS5 protein levels at 6 μM compared to untreated infected cells.
Caused corresponding reductions in viral RNA released into supernatants that mirrored intracellular protein levels.

Western Blot Analysis[2]

Cell Line: Huh-7 cells
Concentration: 6 μM
Incubation Time: 48 h
Result: Caused a significant, selective reduction in RTN3 protein levels (both long and short isoforms) compared to untreated cells, while RTN4, FAM134B, and TMEM41B protein levels remained unchanged.
Reduced RTN3 mRNA levels by approximately 50%, which contributes to but does not fully account for the marked depletion of RTN3 protein.
分子量

313.76

Formula

C15H8ClN3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PS1097 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PS10971822320-58-0PS 1097PS-1097FlavivirusOrthopoxvirusSARS-CoVCHIKVEnterovirusSARS coronavirusChikungunya virus RhinovirusHRVHRVsHEVHEVsBovine Viral Diarrhea VirusNS5 proteinVero E6 cellsBVDV RdRpHuh-7 cellsZika virusMDBK cellsRTN3endoplasmic reticulumReticulon 3Inhibitorinhibitorinhibit

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产品名称：
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HY-186075
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