2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. PXS 25

PXS 25 是一种不依赖阳离子的甘露糖 6-磷酸受体 (CI-M6PR) 抑制剂，可抑制 CI-M6PR 介导的潜伏型 TGF-β1 激活。在常氧条件下，PXS 25 可抑制高糖诱导的近端肾小管细胞中潜伏型 TGF-β1 向活性型 TGF-β1 的转化。在常氧条件下，PXS 25 可抑制高糖诱导的近端肾小管细胞中纤连蛋白 、IV 型胶原蛋白的产生及磷酸化 Smad 2 的表达。PXS 25 在皮肤成纤维细胞中具有抗纤维化特性。PXS 25 可用于糖尿病肾病的研究。

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PXS 25

PXS 25 Chemical Structure

CAS No. : 798546-78-8

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PXS 25 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PXS 25 is a cation-independent mannose 6-phosphate receptor (CI-M6PR) inhibitor that inhibits CI-M6PR-mediated activation of latent TGF-β1. PXS 25 inhibits conversion of high glucose-induced latent TGF-β1 to active TGF-β1 in proximal tubule cells under normoxic conditions. PXS 25 suppresses high glucose-induced fibronectin, collagen IV production, and phosphorylated Smad 2 in proximal tubule cells under normoxic conditions. PXS 25 has antifibrotic properties in skin fibroblasts. PXS 25 can be used for the research of diabetic nephropathy[1].

体外研究
(In Vitro)

PXS 25 (1-200 µM；72 h) 可抑制常氧条件下 HK-2 细胞中高糖诱导的潜在 TGF-β1 活化、下游 Smad2 信号传导及细胞外基质生成，但不影响缺氧相关反应[1]。
PXS 25 (1-1000 µM；72 h) 在常氧或缺氧条件下，无论使用 5 mM 还是 30 mM D-glucose (HY-B0389)，均未对 HK-2 细胞表现出细胞毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PXS 25 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HK-2 cells
Concentration: 1 μM, 10 μM, 100 μM, 200 μM, 1000 μM
Incubation Time: 72 h
Result: Exhibited no cytotoxic effect on HK-2 cells cultured in 5 mM or 30 mM D-glucose under normoxic or hypoxic conditions at concentrations up to 1000 μM.
分子量

362.31

Formula

C15H23O8P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PXS 25 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PXS 25798546-78-8PXS25PXS-25TGF-beta/SmadTransforming growth factor betaSmad signalingextracellular matrix productionphosphorylated Smad 2diabetic nephropathyCI-M6PRfibronectincation-independent mannose 6-phosphate receptorM6P-containing proteinsTGF-β?collagen IVD-glucoseskin fibroblastsHK-2 cellshypoxic conditionsproximal tubule cellsnormoxic conditionsInhibitorinhibitorinhibit

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目录号：
HY-181430
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