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  3. Drug Derivative
  4. Pyrazinoylguanidine

Pyrazinoylguanidine (PZG) 是保钾利尿剂 Amiloride (HY-B0285) 的类似物。Pyrazinoylguanidine 可降低原发性高血压患者的收缩压和舒张压，对降低心率有一定作用，且不影响血清中钠、钾、氯等电解质的浓度。Pyrazinoylguanidine 能减轻 2 型糖尿病患者的高血糖和高胰岛素血症，降低甘油三酯、胆固醇和游离脂肪酸水平，并可逆转噻嗪类利尿剂，如 Hydrochlorothiazide (HY-B0252) 引起的高血糖和高血脂。Pyrazinoylguanidine 能抑制肾小管对尿素的重吸收，从而提高尿素的清除率和排泄量，降低血清尿素浓度，减少其毒性蓄积。

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Pyrazinoylguanidine

Pyrazinoylguanidine Chemical Structure

CAS No. : 60398-24-5

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Pyrazinoylguanidine 相关抗体

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生物活性

Pyrazinoylguanidine (PZG) is an analogue of the potassium sparing diuretic, Amiloride (HY-B0285). Pyrazinoylguanidine can lower the systolic and diastolic blood pressure of patients with primary hypertension, has a certain effect on reducing heart rate, and does not affect the concentrations of electrolytes such as sodium, potassium, and chloride in the blood serum. Pyrazinoylguanidine can reduce the hyperglycemia and hyperinsulinemia in type 2 diabetes, reduce the levels of triglycerides, cholesterol, and free fatty acids, and reverse the hyperglycemia and hyperlipidemia induced by thiazide diuretics, such as Hydrochlorothiazide (HY-B0252). Pyrazinoylguanidine ican nhibit the reabsorption of urea by the renal tubules, thereby increasing the clearance rate and excretion volume of urea, reducing the serum urea concentration, and minimizing its toxic accumulation[1].

分子量

165.15

Formula

C6H7N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pyrazinoylguanidine 相关分类

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Keywords:

Pyrazinoylguanidine60398-24-5PZGDrug DerivativeDrug derivativeInhibitorinhibitorinhibit

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