2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. PZ-1129

PZ-1129 是一种选择性的 5-HT7 受体 (5-HT7 receptor) 配体，其 Ki 值为 7 nM。PZ-1129 对 5-HT1A 受体和 D2 受体的 Ki 值为 159 和 24 nM。PZ-1129 能够抑制由 Gs 信号通路介导的组成型环磷酸腺苷 (cAMP) 生成 (EC50 值为 13.7 nM)。PZ-1129 可用于情感障碍的研究，如抑郁症和双相情感障碍。

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PZ-1129

PZ-1129 Chemical Structure

CAS No. : 1919029-61-0

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PZ-1129 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PZ-1129 is a selective 5-HT7 receptor ligand with a Ki of 7 nM. PZ-1129 shows Ki values of 159 and 24 nM for 5-HT1A receptor and D2 receptor. PZ-1129 can inhibit the constitutive cAMP production mediated by the Gs signaling pathway (EC50 = 13.7 nM). PZ-1129 can be used for the research of emotional disorders, such as depression and bipolar disorder[1].

IC50 & Target[1]

5-HT7 Receptor

7 nM (Ki)

D2 Receptor

24 nM (Ki)

5-HT1A Receptor

159 nM (Ki)

5-HT2A Receptor

113 nM (Ki)

5-HT6 Receptor

524 nM (Ki)

分子量

454.56

Formula

C25H27FN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PZ-1129 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PZ-11291919029-61-0PZ1129PZ 11295-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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产品名称：
PZ-1129
目录号：
HY-179725
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